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Comparative Genomic...
Comparative Genomics Analysis of Keratin-Degrading Chryseobacterium Species Reveals Their Keratinolytic Potential for Secondary Metabolite Production
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- Kang, Dingrong (författare)
- Univ Copenhagen, Dept Biol, Sect Microbiol, DK-2100 Copenhagen, Denmark.;Imperial Coll London, Imperial Coll, Ctr Synthet Biol, London SW7 2AZ, England.;Imperial Coll London, Dept Bioengn, London SW7 2AZ, England.;Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England.;Univ Liege, Gembloux Agrobio Tech, TERRA Res & Teaching Ctr, Microbial Proc & Interact MiPI, B-5030 Gembloux, Belgium.
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- Shoaie, Saeed (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England.
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- Jacquiod, Samuel (författare)
- Univ Bourgogne Franche Comte, INRAE, AgroSup Dijon, Agroecol, F-21000 Dijon, France.
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- Sorensen, Soren J. (författare)
- Univ Copenhagen, Dept Biol, Sect Microbiol, DK-2100 Copenhagen, Denmark.
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- Ledesma-Amaro, Rodrigo (författare)
- Imperial Coll London, Imperial Coll, Ctr Synthet Biol, London SW7 2AZ, England.;Imperial Coll London, Dept Bioengn, London SW7 2AZ, England.
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Univ Copenhagen, Dept Biol, Sect Microbiol, DK-2100 Copenhagen, Denmark;Imperial Coll London, Imperial Coll, Ctr Synthet Biol, London SW7 2AZ, England.;Imperial Coll London, Dept Bioengn, London SW7 2AZ, England.;Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London SE1 9RT, England.;Univ Liege, Gembloux Agrobio Tech, TERRA Res & Teaching Ctr, Microbial Proc & Interact MiPI, B-5030 Gembloux, Belgium. Science for Life Laboratory, SciLifeLab (creator_code:org_t)
- 2021-05-12
- 2021
- Engelska.
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Ingår i: Microorganisms. - : MDPI AG. - 2076-2607. ; 9:5
- Relaterad länk:
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- A promising keratin-degrading strain from the genus Chryseobacterium (Chryseobacterium sp. KMC2) was investigated using comparative genomic tools against three publicly available reference genomes to reveal the keratinolytic potential for biosynthesis of valuable secondary metabolites. Genomic features and metabolic potential of four species were compared, showing genomic differences but similar functional categories. Eleven different secondary metabolite gene clusters of interest were mined from the four genomes successfully, including five common ones shared across all genomes. Among the common metabolites, we identified gene clusters involved in biosynthesis of flexirubin-type pigment, microviridin, and siderophore, showing remarkable conservation across the four genomes. Unique secondary metabolite gene clusters were also discovered, for example, ladderane from Chryseobacterium sp. KMC2. Additionally, this study provides a more comprehensive understanding of the potential metabolic pathways of keratin utilization in Chryseobacterium sp. KMC2, with the involvement of amino acid metabolism, TCA cycle, glycolysis/gluconeogenesis, propanoate metabolism, and sulfate reduction. This work uncovers the biosynthesis of secondary metabolite gene clusters from four keratinolytic Chryseobacterium species and shades lights on the keratinolytic potential of Chryseobacterium sp. KMC2 from a genome-mining perspective, can provide alternatives to valorize keratinous materials into high-value bioactive natural products.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Nyckelord
- keratinous materials
- metabolic potential
- genome mining
- gene clusters
- degradation pathways
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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