onr:"swepub:oai:DiVA.org:kth-298894"
Search: onr:"swepub:oai:DiVA.org:kth-298894" > Revisiting the Role...
- 1 of 1
- Previous record
- Next record
- To hitlist
Revisiting the Role of gamma delta T Cells in Anti-CMV Immune Response after Transplantation
-
- Gaballa, Ahmed (author)
- Karolinska Inst, Dept Clin Sci Intervent & Technol, S-14152 Stockholm, Sweden.;Menoufia Univ, Natl Liver Inst, Dept Biochem & Mol Biol, Shibin Al Kawm 51132, Egypt.
-
- Alagrafi, Faisal (author)
- Karolinska Inst, Dept Clin Sci Intervent & Technol, S-14152 Stockholm, Sweden.;King Abdulaziz City Sci & Technol KACST, Natl Ctr Biotechnol, Riyadh 11442, Saudi Arabia.
-
- Uhlin, Michael (author)
- KTH,Tillämpad fysik,Science for Life Laboratory, SciLifeLab,Karolinska Inst, Dept Clin Sci Intervent & Technol, S-14152 Stockholm, Sweden.;Royal Inst Technol, Dept Appl Phys, Sci Life Lab, S-14152 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Immunol & Transfus Med, S-14152 Stockholm, Sweden.
- show more...
- show less...
- Karolinska Inst, Dept Clin Sci Intervent & Technol, S-14152 Stockholm, Sweden;Menoufia Univ, Natl Liver Inst, Dept Biochem & Mol Biol, Shibin Al Kawm 51132, Egypt. Karolinska Inst, Dept Clin Sci Intervent & Technol, S-14152 Stockholm, Sweden.;King Abdulaziz City Sci & Technol KACST, Natl Ctr Biotechnol, Riyadh 11442, Saudi Arabia. (creator_code:org_t)
- 2021-05-29
- 2021
- English.
- In: Viruses. - : MDPI AG. - 1999-4915. ; 13:6, s. 1031-
- Research review (peer-reviewed)
Abstract
Subject headings
Close
- Gamma delta (gamma delta) T cells form an unconventional subset of T lymphocytes that express a T cell receptor (TCR) consisting of gamma and delta chains. Unlike conventional alpha beta T cells, gamma delta T cells share the immune signature of both the innate and the adaptive immunity. These features allow gamma delta T cells to act in front-line defense against infections and tumors, rendering them an attractive target for immunotherapy. The role of gamma delta T cells in the immune response to cytomegalovirus (CMV) has been the focus of intense research for several years, particularly in the context of transplantation, as CMV reactivation remains a major cause of transplant-related morbidity and mortality. Therefore, a better understanding of the mechanisms that underlie CMV immune responses could enable the design of novel gamma delta T cell-based therapeutic approaches. In this regard, the advent of next-generation sequencing (NGS) and single-cell TCR sequencing have allowed in-depth characterization of CMV-induced TCR repertoire changes. In this review, we try to shed light on recent findings addressing the adaptive role of gamma delta T cells in CMV immunosurveillance and revisit CMV-induced TCR reshaping in the era of NGS. Finally, we will demonstrate the favorable and unfavorable effects of CMV reactive gamma delta T cells post-transplantation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- CMV
- gamma delta
- transplantation
Publication and Content Type
- ref (subject category)
- for (subject category)
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Gaballa, Ahmed
- Alagrafi, Faisal
- Uhlin, Michael
- Stikvoort, Arwen
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Immunology in th ...
- Articles in the publication
- Viruses
- By the university
- Royal Institute of Technology
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
