Multifunctional 3D-Printed Wound Dressings

Alizadehgiashi, MoienUniv Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada. (author)

QC 20210901
Personalized wound dressings provide enhanced healing for different wound types; however multicomponent wound dressings with discretely controllable delivery of different biologically active agents are yet to be developed. Here we report 3D-printed multicomponent biocomposite hydrogel wound dressings that have been selectively loaded with small molecules, metal nanoparticles, and proteins for independently controlled release at the wound site. Hydrogel wound dressings carrying antibacterial silver nanoparticles and vascular endothelial growth factor with predetermined release profiles were utilized to study the physiological response of the wound in a mouse model. Compared to controls, the application of dressings resulted in improvement in granulation tissue formation and differential levels of vascular density, dependent on the release profile of the growth factor. Our study demonstrates the versatility of the 3D-printed hydrogel dressings that can yield varied physiological responses in vivo and can further be adapted for personalized treatment of various wound types.

Nemr, Carine R.Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada. (author)
Chekini, MahshidUniv Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada. (author)
Ramos, Daniel PintoUniv Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada. (author)
Mittal, NiteshKTH,Strömningsfysik,Linné Flow Center, FLOW,Wallenberg Wood Science Center,Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada(Swepub:kth)u16e8jvr (author)
Ahmed, Sharif U.Univ Toronto, Dept Pharmaceut Sci, Toronto, ON M5S 3M2, Canada. (author)
Khuu, NancyUniv Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada. (author)
Kelley, Shana O.Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada.;Univ Toronto, Dept Pharmaceut Sci, Toronto, ON M5S 3M2, Canada.;Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada. (author)
Kumacheva, EugeniaUniv Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada.;Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada.;Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON M5S 3E5, Canada. (author)
Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada.Strömningsfysik (creator_code:org_t)

In:ACS Nano: American Chemical Society (ACS)15:7, s. 12375-123871936-08511936-086X

By the author/editor: Alizadehgiashi, ...; Nemr, Carine R.; Chekini, Mahshid; Ramos, Daniel Pi ...; Mittal, Nitesh; Ahmed, Sharif U.; show more...; Khuu, Nancy; Kelley, Shana O.; Kumacheva, Eugen ...; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Chemical Science ...; and Polymer Chemistr ...

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