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Antibody responses ...
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Havervall, SebastianKarolinska Institutet,Danderyd Hosp, Karolinska Inst, Dept Clin Sci, S-18288 Stockholm, Sweden.
(author)
Antibody responses after a single dose of ChAdOx1 nCoV-19 vaccine in healthcare workers previously infected with SARS-CoV-2
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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Elsevier BV,2021
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-302036
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-302036URI
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https://doi.org/10.1016/j.ebiom.2021.103523DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:147495597URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-455992URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20210920
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Background: Recent reports demonstrate robust serological responses to a single dose of messenger RNA (mRNA) vaccines in individuals previously infected with SARS-CoV-2. Data on immune responses following a single-dose adenovirus-vectored vaccine expressing the SARS-CoV-2 spike protein (ChAdOx1 nCoV-19) in individuals with previous SARS-CoV-2 infection are however limited, and current guidelines recommend a two-dose regimen regardless of preexisting immunity. Methods: We compared RBD-specific IgG and RBD-ACE2 blocking antibodies against SARS-CoV-2 wild type and variants of concern following two doses of the mRNA vaccine BNT162b2 in SARS-CoV-2 naive healthcare workers (n=65) and a single dose of the adenovector vaccine ChAdOx1 nCoV-19 in 82 healthcare workers more than (n=45) and less than (n=37) 11 months post mild SARS-CoV-2 infection at time of vaccination. Findings: The post-vaccine levels of RBD-specific IgG and neutralizing antibodies against the SARS-CoV-2 wild type and variants of concern including Delta lineage 1.617.2 were similar or higher in participants receiving a single dose of ChAdOx1 nCoV-19 vaccine post SARS-CoV-2 infection (both more than and less than 11 months post infection) compared to SARS-CoV-2 naive participants who received two doses of BNT162b2 vaccine. Interpretation: Our data support that a single dose ChAdOx1 nCoV-19 vaccine that is administered up to at least 11 months post SARS-CoV-2 infection serves as an effective immune booster. This provides a possible rationale for a single-dose vaccine regimen. (C) 2021 The Author(s). Published by Elsevier B.V.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Marking, UlrikaKarolinska Institutet,Danderyd Hosp, Karolinska Inst, Dept Clin Sci, S-18288 Stockholm, Sweden.
(author)
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Greilert-Norin, NinaDanderyd Hosp, Karolinska Inst, Dept Clin Sci, S-18288 Stockholm, Sweden.
(author)
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Ng, HenryUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk cellbiologi,Danderyd Hosp, Karolinska Inst, Dept Clin Sci, S-18288 Stockholm, Sweden.(Swepub:uu)henng887
(author)
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Gordon, MaxKarolinska Institutet,Danderyd Hosp, Karolinska Inst, Dept Clin Sci, S-18288 Stockholm, Sweden.
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Salomonsson, Ann-ChristinDanderyd Hosp, Karolinska Inst, Dept Clin Sci, S-18288 Stockholm, Sweden.
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Hellström, CeciliaKTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,KTH Royal Inst Technol, Dept Prot Sci, SciLifeLab, Stockholm, Sweden.(Swepub:kth)u1doy1fn
(author)
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Pin, ElisaKTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Prot Sci, SciLifeLab, Stockholm, Sweden.(Swepub:kth)u1pmjyje
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Blom, KimKarolinska Institutet,Publ Hlth Agcy Sweden, Solna, Sweden.
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Mangsbo, Sara,1981-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för farmaceutisk biovetenskap(Swepub:uu)saman132
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Phillipson, MiaUppsala Univ, Dept Med Cell Biol, Sci Life Lab, Uppsala, Sweden.
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Klingström, JonasKarolinska Institutet,Publ Hlth Agcy Sweden, Solna, Sweden.;Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden.
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Hober, Sophia,Professor,1965-KTH,Science for Life Laboratory, SciLifeLab,Proteinteknologi,KTH Royal Inst Technol, Dept Prot Sci, SciLifeLab, Stockholm, Sweden.(Swepub:kth)u11qqzc1
(author)
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Nilsson, PeterKTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,KTH Royal Inst Technol, Dept Prot Sci, SciLifeLab, Stockholm, Sweden.(Swepub:kth)u1ws88sk
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Åberg, MikaelUppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk kemi(Swepub:uu)miabe173
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Thalin, CharlotteKarolinska Institutet,Danderyd Hosp, Karolinska Inst, Dept Clin Sci, S-18288 Stockholm, Sweden.
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Karolinska InstitutetDanderyd Hosp, Karolinska Inst, Dept Clin Sci, S-18288 Stockholm, Sweden.
(creator_code:org_t)
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In:EBioMedicine: Elsevier BV702352-3964
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