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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04914naa a2200469 4500 | |
| 001 | oai:DiVA.org:kth-302607 | |
| 003 | SwePub | |
| 008 | 211027s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3026072 URI |
| 024 | 7 | a https://doi.org/10.1192/j.eurpsy.2021.20262 DOI |
| 040 | a (SwePub)kth | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a vet2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Schubert, K. O.u Univ Adelaide, Discipline Psychiat, Adelaide, SA, Australia.;Northern Adelaide Mental Hlth Serv, Commun Mental Hlth, Salisbury, SA, Australia.4 aut |
| 245 | 1 0 | a Autoantibody profiles are associated with specific clinical features in psychotic disorders |
| 264 | c 2021-08-13 | |
| 264 | 1 | b Cambridge University Press,c 2021 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20211027 | |
| 520 | a Immune system abnormalities exist across a range of psychiatric disorders. Autoimmunity, characterized by the production of antibodies against the body’s own antigens, is a feature of immune system dysfunction and could play a role in mental disorder pathophysiology. Better understanding of the associations of auto-immunoglobulin G (IgG) repertoires with clinical features of mental illness could yield novel models of psychosis pathophysiology and markers for biological patient stratification.ObjectivesTo undertake global screening for auto-IgG expression in a large cohort of people with psychotic disorders; to determine whether associations exist between autoantibody expression and clinical features.MethodsCross-sectional quantification of auto-IgGs in blood plasma of 461 people with established psychotic disorder diagnoses. For global screening, pooled samples of phenotypically representative patient groups were exposed to planar protein microarrays containing 42,000 human antigens. For targeted profiling, expression levels of 380 autoantibodies were quantified by suspension bead array (SBA) in each patient’s plasma.ResultsWe identified highly individual autoantibody profiles with no evidence for co-expression patterns. We found 6 autoantibodies robustly associated with specific psychopathology: anti-AP3B2, detected in 5% of the cohort of whom 100% had persecutory delusions; anti-TDO2 (5% of the cohort, 100% hallucinations); anti-CRYGN (4%, 86% initial insomnia); anti-APMAP (3%, 86% poor appetite); anti-OLFM1 (2.5%, 100% above median cognitive function); and anti-WHAMMP3 (2%, 90% anhedonia and dysphoria). Examination of the auto-IgG binding site on the TDO2 protein revealed a putative pathophysiological mechanism involving the kynurenine pathway.ConclusionsWe identified 6 frequently occurring autoantibodies that were associated with specific clinical features in people with psychotic disorders.DisclosureNo significant relationships. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
| 653 | a Autoimmunity | |
| 653 | a Autoantibodies | |
| 653 | a psychopathology | |
| 653 | a psychosis | |
| 700 | 1 | a Jernbom Falk, Augustu KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1db8k5t |
| 700 | 1 | a Galletly, C.u Univ Adelaide, Discipline Psychiat, Adelaide, SA, Australia.;Northern Adelaide Mental Hlth Serv, Commun Mental Hlth, Salisbury, SA, Australia.4 aut |
| 700 | 1 | a Just, Davidu KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u12e3k9u |
| 700 | 1 | a Toben, C.u Univ Adelaide, Discipline Psychiat, Adelaide, SA, Australia.4 aut |
| 700 | 1 | a Baune, B.u Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia.;Univ Munster, Dept Psychiat & Psychotherapy, Munster, Germany.4 aut |
| 700 | 1 | a Clark, S.u Univ Adelaide, Discipline Psychiat, Adelaide, SA, Australia.4 aut |
| 700 | 1 | a Liu, D.u Univ Adelaide, Discipline Psychiat, Adelaide, SA, Australia.4 aut |
| 700 | 1 | a Nilsson, Peteru KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1ws88sk |
| 700 | 1 | a Månberg, Anna,d 1985-u KTH,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1g5roxd |
| 710 | 2 | a Univ Adelaide, Discipline Psychiat, Adelaide, SA, Australia.;Northern Adelaide Mental Hlth Serv, Commun Mental Hlth, Salisbury, SA, Australia.b Science for Life Laboratory, SciLifeLab4 org |
| 773 | 0 | t European psychiatryd : Cambridge University Pressg 64q 64x 0924-9338x 1778-3585 |
| 856 | 4 | u https://www.cambridge.org/core/services/aop-cambridge-core/content/view/2D8348EC4D9FDF0B291A1C7CF1EF0340/S0924933821020265a.pdf/div-class-title-autoantibody-profiles-are-associated-with-specific-clinical-features-in-psychotic-disorders-div.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-302607 |
| 856 | 4 8 | u https://doi.org/10.1192/j.eurpsy.2021.2026 |
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