Continuous monitoring of isogenic blood-brain barrier integrity in a pdms-free microphysiological system

• We present a microphysiological system (MPS) of the human blood-brain barrier (BBB) that uniquely combines three key advantages - continuous monitoring, PDMS-free fabrication, and cellular relevance - over existing MPS, and we demonstrate BBB formation, breakdown, and rescue. Specifically, we model nitrosative stress - strongly implicated in brain-related disorders from stroke to Alzheimer's - and its prevention using a BBB-permeable antioxidant. This kind of MPS paves the way toward patient-specific BBB modeling for time-resolved studies of drug kinetics and/or side effects towards personalized treatment planning.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)

Keyword

Blood Brain Barrier

HiPSC Co-Culture

Impedimetric Sensing

Microphysiological System

Monitoring

Patient treatment

Pharmacokinetics

Blood-brain barrier

Continuous monitoring

Human bloods

Nitrosative stress

Patient specific

Side effect

Time resolved studies

Treatment planning

Blood

Publication and Content Type

ref (subject category)

kon (subject category)