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Development of humo...
Development of humoral and cellular immunological memory against SARS-CoV-2 despite B cell depleting treatment in multiple sclerosis
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- Högelin, Klara Asplund (author)
- Karolinska Institutet
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- Ruffin, Nicolas (author)
- Karolinska Institutet
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- Pin, Elisa (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- Månberg, Anna, 1985- (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Hober, Sophia, Professor, 1965- (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinteknologi
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- Gafvelin, Guro (author)
- Karolinska Inst, Ctr Mol Med L8 02, Dept Clin Neurosci, Therapeut Immune Design Unit, S-17176 Stockholm, Sweden.
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- Grönlund, Hans (author)
- Karolinska Institutet
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- Nilsson, Peter (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Khademi, Mohsen (author)
- Karolinska Institutet
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- Olsson, Tomas (author)
- Karolinska Institutet
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- Piehl, Fredrik (author)
- Karolinska Institutet
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- Al Nimer, Faiez (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: iScience. - : Elsevier BV. - 2589-0042. ; 24:9
- Related links:
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https://doi.org/10.1...
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http://www.cell.com/...
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Abstract
Subject headings
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- B cell depleting therapies (BCDTs) are widely used as immunomodulating agents for autoimmune diseases such as multiple sclerosis. Their possible impact on development of immunity to severe acute respiratory syndrome virus-2 (SARS-CoV-2) has raised concerns with the coronavirus disease 2019 (COVID-19) pandemic. We here evaluated the frequency of COVID-19-like symptoms and determined immunological responses in participants of an observational trial comprising several multiple sclerosis disease modulatory drugs (COMBAT-MS; NCT03193866) and in eleven patients after vaccination, with a focus on BCDT. Almost all seropositive and 17.9% of seronegative patients on BCDT, enriched for a history of COVID-19-like symptoms, developed anti-SARS-CoV-2 T cell memory, and T cells displayed functional similarity to controls producing IFN-gamma and TNF. Following vaccination, vaccine-specific humoral memory was impaired, while all patients developed a specific T cell response. These results indicate that BCDTs do not abrogate SARS-CoV-2 cellular memory and provide a possible explanation as to why the majority of patients on BCDTs recover from COVID-19.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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iScience
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- By the author/editor
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Högelin, Klara A ...
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Ruffin, Nicolas
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Pin, Elisa
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Månberg, Anna, 1 ...
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Hober, Sophia, P ...
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Gafvelin, Guro
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show more...
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Grönlund, Hans
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Nilsson, Peter
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Khademi, Mohsen
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Olsson, Tomas
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Piehl, Fredrik
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Al Nimer, Faiez
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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iScience
- By the university
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Royal Institute of Technology
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Karolinska Institutet