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Mechanical characterisation of the human dura mater, falx cerebri and superior sagittal sinus
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- Walsh, Darragh R. (author)
- Univ Limerick, Bernal Inst, Limerick, Ireland.;Univ Limerick, Sch Engn, Limerick, Ireland.
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- Ross, Aisling M. (author)
- Univ Limerick, Bernal Inst, Limerick, Ireland.;Univ Limerick, Sch Engn, Limerick, Ireland.
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- Newport, David T. (author)
- Univ Limerick, Bernal Inst, Limerick, Ireland.;Univ Limerick, Sch Engn, Limerick, Ireland.;Univ Limerick, Hlth Res Inst, Limerick, Ireland.
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- Univ Limerick, Bernal Inst, Limerick, Ireland;Univ Limerick, Sch Engn, Limerick, Ireland. Univ Limerick, Bernal Inst, Limerick, Ireland.;Univ Limerick, Sch Engn, Limerick, Ireland.;Univ Limerick, Hlth Res Inst, Limerick, Ireland. (creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
- In: Acta Biomaterialia. - : Elsevier BV. - 1742-7061 .- 1878-7568. ; 134, s. 388-400
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The cranial meninges have been shown to play a pivotal role in traumatic brain injury mechanopathology. However, while the mechanical response of the brain and its many subregions have been studied extensively, the meninges have conventionally been overlooked. This paper presents the first comparative mechanical analysis of human dura mater, falx cerebri and superior sagittal sinus tissues. Biaxial tensile analysis identified that these tissues are mechanically heterogeneous, in contrast to the assumption that the tissues are mechanically homogeneous which is typically employed in FE model design. A thickness of 0.91 +/- 0.05 (standard error) mm for the falx cerebri was also identified. This data can aid in improving the biofidelity of the influential falx structure in FE models. Additionally, the use of a collagen hybridizing peptide on the superior sagittal sinus suggests this structure is particularly susceptible to the effects of circumf erential stretch, which may have important implications for clinical treatment of dural venous sinus pathologies. Collectively, this research progresses understanding of meningeal mechanical and structural characteristics and may aid in elucidating the behaviour of these tissues in healthy and diseased conditions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Traumatic brain injury (TBI)
- Biomechanics
- Meninges
- Collagen hybridizing peptide (CHP)
- Structural damage analysis
Publication and Content Type
- ref (subject category)
- art (subject category)
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