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Immune infiltration...
Immune infiltration and prognostic and diagnostic use of LGALS4 in colon adenocarcinoma and bladder urothelial carcinoma
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- Acharjee, Animesh (author)
- Univ Birmingham, Coll Med & Dent Sci, Inst Canc & Genom Sci, Birmingham B15 2TT, W Midlands, England.;Fdn Trust, Univ Hosp Birmingham NHS, Inst Translat Med, Birmingham B15 2TT, W Midlands, England.;Univ Hosp Birmingham, NIHR Surg Reconstruct & Microbiol Res Ctr, Birmingham B15 2WB, W Midlands, England.
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- Agarwal, Prasoon (author)
- KTH,Beräkningsvetenskap och beräkningsteknik (CST)
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- Nash, Katrina (author)
- Univ Birmingham, Coll Med & Dent Sci, Birmingham B15 2TT, W Midlands, England.
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- Bano, Subia (author)
- Elvesys Microfluid Innovat Ctr, F-75011 Paris, France.
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- Rahmans, Taufiq (author)
- Univ Cambridge, Dept Pharmacol, Tennis Court Rd, Cambridge CB2 1PD, England.
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- Gkoutos, Georgios, V (author)
- Univ Birmingham, Coll Med & Dent Sci, Inst Canc & Genom Sci, Birmingham B15 2TT, W Midlands, England.;Fdn Trust, Univ Hosp Birmingham NHS, Inst Translat Med, Birmingham B15 2TT, W Midlands, England.;Univ Hosp Birmingham, NIHR Surg Reconstruct & Microbiol Res Ctr, Birmingham B15 2WB, W Midlands, England.;MRC Hlth Data Res UK HDR UK, London, England.;NIHR Expt Canc Med Ctr, Birmingham B15 2TT, W Midlands, England.;Univ Hosp Birmingham, NIHR Biomed Res Ctr, Birmingham B15 2TT, W Midlands, England.
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Univ Birmingham, Coll Med & Dent Sci, Inst Canc & Genom Sci, Birmingham B15 2TT, W Midlands, England;Fdn Trust, Univ Hosp Birmingham NHS, Inst Translat Med, Birmingham B15 2TT, W Midlands, England.;Univ Hosp Birmingham, NIHR Surg Reconstruct & Microbiol Res Ctr, Birmingham B15 2WB, W Midlands, England. Beräkningsvetenskap och beräkningsteknik (CST) (creator_code:org_t)
- E-Century Publishing Corporation, 2021
- 2021
- English.
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In: American Journal of Translational Research. - : E-Century Publishing Corporation. - 1943-8141. ; 13:10, s. 11353-11363
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
Close
- Colon adenocarcinoma (COAD) is a common tumor of the gastrointestinal tract with a high mortality rate. Current research has identified many genes associated with immune infiltration that play a vital role in the development of COAD. In this study, we analysed the prognostic and diagnostic features of such immune-related genes in the context of colonic adenocarcinoma (COAD). We analysed 17 overlapping gene expression profiles of COAD and healthy samples obtained from TCGA-COAD and public single-cell sequencing resources, to identify potential therapeutic COAD targets. We evaluated the abundance of immune infiltration with those genes using the TIMER (Tumor Immune Estimation Resource) deconvolution method. Subsequently, we developed predictive and survival models to assess the prognostic value of these genes. The LGALS4 (Galectin-4) gene was found to be significantly (P<0.05) downregulated in COAD and bladder urothelial carcinoma (BLCA) compared to healthy samples. We identified LGALS4 as a prognostic and diagnostic marker for multiple cancer types, including COAD and BLCA. Our analysis reveals a series of novel candidate drug targets, as well as candidate molecular markers, that may explain the pathogenesis of COAD and BLCA. LGALS4 gene is associated with multiple cancer types and is a possible prognostic, as well as diagnostic, marker of COAD and BLCA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Omics integration
- translational research
- immune infiltration
- LGALS4
- biomarker
- BLCA
Publication and Content Type
- ref (subject category)
- art (subject category)
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