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Identification of E...
Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors
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- Iglesias, Maria Jesus (author)
- KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Univ Hosp North Norway, Div Internal Med, Tromso, Norway.
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- Kruse, Larissa D. (author)
- KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab
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- Sanchez-Rivera, Laura (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap
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- Enge, Linnea (author)
- KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab
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- Dusart, Philip (author)
- KTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab
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- Hong, Mun-Gwan (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap
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- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi
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- Renne, Thomas (author)
- Univ Med Ctr Hamburg Eppendorf, Inst Clin Chem & Lab Med, Hamburg, Germany.;Royal Coll Surgeons Ireland, Irish Ctr Vasc Biol, Sch Pharm & Biomol Sci, Dublin, Ireland.;Johannes Gutenberg Univ Mainz, Ctr Thrombosis & Hemostasis CTH, Med Ctr, Mainz, Germany.
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- Schwenk, Jochen M. (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Bergstrom, Goran (author)
- Univ Gothenburg, Inst Med, Sahlgrenska Acad, Gothenburg, Sweden.
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- Odeberg, Jacob, Professor, 1963- (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,Univ Hosp North Norway, Div Internal Med, Tromso, Norway.;Arctic Univ Norway, Dept Clin Med, Tromso, Norway.;Karolinska Univ Hosp, Dept Hematol, Coagulat Unit, Stockholm, Sweden.
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- Butler, Lynn M. (author)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Karolinska Inst, Dept Mol Med & Surg, Clin Chem & Blood Coagulat Res, SE-17176 Stockholm, Sweden.;Arctic Univ Norway, Dept Clin Med, Tromso, Norway.;Karolinska Univ Hosp, Karolinska Univ Lab, Clin Chem, Stockholm, Sweden.
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2021
- 2021
- English.
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In: Arteriosclerosis, Thrombosis and Vascular Biology. - : Ovid Technologies (Wolters Kluwer Health). - 1079-5642 .- 1524-4636. ; 41:12, s. 2990-3004
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective: Endothelial cell (EC) dysfunction is a well-established response to cardiovascular disease risk factors, such as smoking and obesity. Risk factor exposure can modify EC signaling and behavior, leading to arterial and venous disease development. Here, we aimed to identify biomarker panels for the assessment of EC dysfunction, which could be useful for risk stratification or to monitor treatment response. Approach and Results: We used affinity proteomics to identify EC proteins circulating in plasma that were associated with cardiovascular disease risk factor exposure. Two hundred sixteen proteins, which we previously predicted to be EC-enriched across vascular beds, were measured in plasma samples (N=1005) from the population-based SCAPIS (Swedish Cardiopulmonary Bioimage Study) pilot. Thirty-eight of these proteins were associated with body mass index, total cholesterol, low-density lipoprotein, smoking, hypertension, or diabetes. Sex-specific analysis revealed that associations predominantly observed in female- or male-only samples were most frequently with the risk factors body mass index, or total cholesterol and smoking, respectively. We show a relationship between individual cardiovascular disease risk, calculated with the Framingham risk score, and the corresponding biomarker profiles. Conclusions: EC proteins in plasma could reflect vascular health status.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- cardiovascular diseases
- endothelium
- hypertension
- risk factors
- smoking
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Iglesias, Maria ...
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Kruse, Larissa D ...
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Sanchez-Rivera, ...
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Enge, Linnea
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Dusart, Philip
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Hong, Mun-Gwan
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Uhlén, Mathias
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Renne, Thomas
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Schwenk, Jochen ...
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Bergstrom, Goran
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Odeberg, Jacob, ...
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Butler, Lynn M.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Arteriosclerosis ...
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Royal Institute of Technology
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Karolinska Institutet