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A hierarchical clas...
A hierarchical classification of polysaccharide lyases for glycogenomics
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Lombard, Vincent (author)
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Bernard, Thomas (author)
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Rancurel, Corinne (author)
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- Brumer, Harry (author)
- KTH,Glykovetenskap
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Coutinho, Pedro M. (author)
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Henrissat, Bernard (author)
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(creator_code:org_t)
- 2010
- 2010
- English.
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In: Biochemical Journal. - 0264-6021 .- 1470-8728. ; 432, s. 437-444
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Carbohydrate-active enzymes face huge substrate diversity in a highly selective manner using only a limited number of available folds. They are therefore subjected to multiple divergent and convergent evolutionary events. This and their frequent modularity render their functional annotation in genomes difficult in a number of cases. In the present paper, a classification of polysaccharide lyases (the enzymes that cleave polysaccharides using an elimination instead of a hydrolytic mechanism) is shown thoroughly for the first time. Based on the analysis of a large panel of experimentally characterized polysaccharide lyases, we examined the correlation of various enzyme properties with the three levels of the classification: fold, family and subfamily. The resulting hierarchical classification, which should help annotate relevant genes in genomic efforts, is available and constantly updated at the Carbohydrate-Active Enzymes Database (http://www.cazy.org).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- catalytic mechanism
- enzyme family
- functional annotation
- modular structure
- polysaccharide lyase
- Biochemistry
- Biokemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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