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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007979naa a2200649 4500
001oai:DiVA.org:kth-308672
003SwePub
008220215s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3086722 URI
0247 a https://doi.org/10.3390/cancers140204492 DOI
040 a (SwePub)kth
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Juanes-Velasco, Pablou Univ Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.4 aut
2451 0a Deciphering Biomarkers for Leptomeningeal Metastasis in Malignant Hemopathies (Lymphoma/Leukemia) Patients by Comprehensive Multipronged Proteomics Characterization of Cerebrospinal Fluid
264 c 2022-01-17
264 1b MDPI AG,c 2022
338 a print2 rdacarrier
500 a QC 20220215
520 a Simple Summary The early diagnosis of leptomeningeal disease is a challenge because it is asymptomatic in the early stages. Consequently, it is important to identify a panel of biomarkers to help in its diagnosis and/or prognosis. For this purpose, we explored a multipronged proteomics approach in cerebrospinal fluid (CSF) to determine a potential panel of biomarkers. Thus, a systematic and exhaustive characterization of more than 300 CSF samples was performed by an integrated approach by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) and functional proteomics analysis to establish protein profiles, which were useful for developing a panel of biomarkers validated by in silico approaches. In the present work, leptomeningeal disease, a very destructive form of systemic cancer, was characterized from several proteomics points of view. This pathology involves the invasion of the leptomeninges by malignant tumor cells. The tumor spreads to the central nervous system through the cerebrospinal fluid (CSF) and has a very grim prognosis; the average life expectancy of patients who suffer it does not exceed 3 months. The early diagnosis of leptomeningeal disease is a challenge because, in most of the cases, it is an asymptomatic pathology. When the symptoms are clear, the disease is already in the very advanced stages and life expectancy is low. Consequently, there is a pressing need to determine useful CSF proteins to help in the diagnosis and/or prognosis of this disease. For this purpose, a systematic and exhaustive proteomics characterization of CSF by multipronged proteomics approaches was performed to determine different protein profiles as potential biomarkers. Proteins such as PTPRC, SERPINC1, sCD44, sCD14, ANPEP, SPP1, FCGR1A, C9, sCD19, and sCD34, among others, and their functional analysis, reveals that most of them are linked to the pathology and are not detected on normal CSF. Finally, a panel of biomarkers was verified by a prediction model for leptomeningeal disease, showing new insights into the research for potential biomarkers that are easy to translate into the clinic for the diagnosis of this devastating disease.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a cerebrospinal fluid (CSF)
653 a leptomeningeal metastasis (LM)
653 a biomarkers
653 a high-abundant protein depletion
653 a CSF-stabilizing reagents
653 a tumor infiltrating
653 a modelling leptomeningeal disease
653 a proteomic analysis
653 a LC-MS
653 a MS
653 a protein microarrays
653 a protein-based biomarker
7001 a Galicia, Normau Univ Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Prote Unit, Canc Res Ctr IBMCC,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.4 aut
7001 a Pin, Elisau KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1pmjyje
7001 a Jara-Acevedo, Ricardou Univ Coimbra, Immunostep SL Inst Canc Res, Av Univ Coimbra, Salamanca 37007, Spain.4 aut
7001 a Carabias-Sanchez, Javieru Univ Salamanca, CSIC, Prote Unit, Canc Res Ctr IBMCC,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.4 aut
7001 a Garcia-Valiente, Rodrigou Univ Salamanca, CSIC, Prote Unit, Canc Res Ctr IBMCC,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.4 aut
7001 a Lecrevisse, Quentinu Univ Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.4 aut
7001 a Pedreira, Carlos Eduardou Univ Fed Rio de Janeiro UFRJ, Syst & Comp Dept COPPE PESC, BR-21941914 Rio De Janeiro, Brazil.4 aut
7001 a Gongora, Rafaelu Univ Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.4 aut
7001 a Sanchez-Santos, Jose Manuelu Univ Salamanca, Stat Dept, Salamanca 37008, Spain.4 aut
7001 a Lorenzo-Gil, Hectoru Univ Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.4 aut
7001 a Landeira-Vinuela, Aliciau Univ Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.4 aut
7001 a Bareke, Halinu Univ Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.4 aut
7001 a Orfao, Albertou Univ Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.4 aut
7001 a Nilsson, Peteru KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1ws88sk
7001 a Fuentes, Manuelu Univ Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Prote Unit, Canc Res Ctr IBMCC,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.4 aut
7102 a Univ Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.b Univ Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Prote Unit, Canc Res Ctr IBMCC,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.4 org
7730 t Cancersd : MDPI AGg 14:2q 14:2x 2072-6694
8564 u https://doi.org/10.3390/cancers14020449y Fulltext
8564 u https://www.mdpi.com/2072-6694/14/2/449/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-308672
8564 8u https://doi.org/10.3390/cancers14020449

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