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Three-dimensional s...
Three-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synovium
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- Vickovic, Sanja (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Broad Institute of MIT and Harvard, USA; Massachusetts Institute of Technology, USA; New York Genome Center, USA
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- Schapiro, Denis (author)
- Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.;Harvard Med Sch, Lab Syst Pharmacol, Boston, MA 02115 USA.;Heidelberg Univ Hosp, Sci Life Lab, Fac Med, Heidelberg, Germany.;Heidelberg Univ Hosp, Inst Pathol, Fac Med, Heidelberg, Germany.;Heidelberg Univ, Heidelberg, Germany.
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- Carlberg, Konstantin (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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- Lötstedt, Britta (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.
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- Larsson, Ludvig (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Hildebrandt, Franziska (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Korotkova, Marina (author)
- Karolinska Institutet
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- Hensvold, Aase H. (author)
- Karolinska Institutet
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- Catrina, Anca, I (author)
- Karolinska Inst, Ctr Mol Med, Dept Med, Div Rheumatol, Stockholm, Sweden.;Karolinska Univ Hosp, Unit Rheumatol, Stockholm, Sweden.
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- Sorger, Peter K. (author)
- Harvard Med Sch, Lab Syst Pharmacol, Boston, MA 02115 USA.
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- Malmstrom, Vivianne (author)
- Karolinska Institutet
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- Regev, Aviv (author)
- Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.;MIT, Howard Hughes Med Inst, Cambridge, MA USA.;MIT, Dept Biol, Koch Inst Integrat Canc Res, Cambridge, MA USA.;Genentech Inc, 1 DNA Way, San Francisco, CA USA.
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- Ståhl, Patrik, Dr. (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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(creator_code:org_t)
- 2022-02-11
- 2022
- English.
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In: Communications Biology. - : Springer Nature. - 2399-3642. ; 5:1
- Related links:
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Abstract
Subject headings
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- The inflamed rheumatic joint is a highly heterogeneous and complex tissue with dynamic recruitment and expansion of multiple cell types that interact in multifaceted ways within a localized area. Rheumatoid arthritis synovium has primarily been studied either by immunostaining or by molecular profiling after tissue homogenization. Here, we use Spatial Transcriptomics, where tissue-resident RNA is spatially labeled in situ with barcodes in a transcriptome-wide fashion, to study local tissue interactions at the site of chronic synovial inflammation. We report comprehensive spatial RNA-Seq data coupled to cell type-specific localization patterns at and around organized structures of infiltrating leukocyte cells in the synovium. Combining morphological features and high-throughput spatially resolved transcriptomics may be able to provide higher statistical power and more insights into monitoring disease severity and treatment-specific responses in seropositive and seronegative rheumatoid arthritis. Sanja Vickovic et al. use spatial transcriptomics to probe the local synovial tissue interactions in rheumatoid arthritis (RA) patients. Their results provide a valuable resource to understand the spatial organisation of cell populations in the synovium in the context of RA-associated inflammation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Vickovic, Sanja
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Schapiro, Denis
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Carlberg, Konsta ...
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Lötstedt, Britta
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Larsson, Ludvig
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Hildebrandt, Fra ...
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show more...
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Korotkova, Marin ...
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Hensvold, Aase H ...
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Catrina, Anca, I
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Sorger, Peter K.
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Malmstrom, Vivia ...
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Regev, Aviv
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Ståhl, Patrik, D ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Communications B ...
- By the university
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Royal Institute of Technology
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Stockholm University
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Karolinska Institutet