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The Blood Proteoform Atlas : A reference map of proteoforms in human hematopoietic cells

Melani, Rafael D. (author)
Northwestern Univ, Dept Mol Biosci, Dept Chem, Evanston, IL 60208 USA.;Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA.
Gerbasi, Vincent R. (author)
Northwestern Univ, Dept Mol Biosci, Dept Chem, Evanston, IL 60208 USA.;Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA.
Anderson, Lissa C. (author)
Florida State Univ, Natl High Magnet Field Lab, Tallahassee, FL USA.
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Sikora, Jacek W. (author)
Northwestern Univ, Dept Mol Biosci, Dept Chem, Evanston, IL 60208 USA.;Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA.
Toby, Timothy K. (author)
Northwestern Univ, Dept Mol Biosci, Dept Chem, Evanston, IL 60208 USA.;Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA.
Hutton, Josiah E. (author)
Northwestern Univ, Dept Mol Biosci, Dept Chem, Evanston, IL 60208 USA.;Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA.
Butcher, David S. (author)
Florida State Univ, Natl High Magnet Field Lab, Tallahassee, FL USA.
Negrao, Fernanda (author)
Northwestern Univ, Dept Mol Biosci, Dept Chem, Evanston, IL 60208 USA.;Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA.
Seckler, Henrique S. (author)
Northwestern Univ, Dept Mol Biosci, Dept Chem, Evanston, IL 60208 USA.;Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA.
Srzentic, Kristina (author)
Northwestern Univ, Dept Mol Biosci, Dept Chem, Evanston, IL 60208 USA.;Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA.
Fornelli, Luca (author)
Northwestern Univ, Dept Mol Biosci, Dept Chem, Evanston, IL 60208 USA.;Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA.
Camarillo, Jeannie M. (author)
Northwestern Univ, Dept Mol Biosci, Dept Chem, Evanston, IL 60208 USA.;Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA.
LeDuc, Richard D. (author)
Northwestern Univ, Dept Mol Biosci, Dept Chem, Evanston, IL 60208 USA.;Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA.
Cesnik, Anthony J. (author)
KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Stanford Univ, Dept Genet, Stanford, CA 94305 USA.
Lundberg, Emma (author)
KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Stanford Univ, Dept Genet, Stanford, CA 94305 USA.
Greer, Joseph B. (author)
Northwestern Univ, Dept Mol Biosci, Dept Chem, Evanston, IL 60208 USA.;Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA.
Fellers, Ryan T. (author)
Northwestern Univ, Dept Mol Biosci, Dept Chem, Evanston, IL 60208 USA.;Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA.
Robey, Matthew T. (author)
Northwestern Univ, Dept Mol Biosci, Dept Chem, Evanston, IL 60208 USA.;Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA.
DeHart, Caroline J. (author)
Northwestern Univ, Dept Mol Biosci, Dept Chem, Evanston, IL 60208 USA.;Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA.
Forte, Eleonora (author)
Northwestern Univ, Prote Ctr Excellence, Evanston, IL USA.;Northwestern Univ, Feinberg Sch Med, Dept Surg, Chicago, IL USA.
Hendrickson, Christopher L. (author)
Florida State Univ, Natl High Magnet Field Lab, Tallahassee, FL USA.
Abbatiello, Susan E. (author)
Thermo Fisher Sci, Cambridge, MA USA.
Thomas, Paul M. (author)
Northwestern Univ, Dept Mol Biosci, Dept Chem, Evanston, IL 60208 USA.;Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA.
Kokaji, Andy, I (author)
STEMCELL Technol Inc, Vancouver, BC, Canada.
Levitsky, Josh (author)
Northwestern Univ, Comprehens Transplant Ctr, Feinberg Sch Med, Chicago, IL 60208 USA.
Kelleher, Neil L. (author)
Northwestern Univ, Dept Mol Biosci, Dept Chem, Evanston, IL 60208 USA.;Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA.;Northwestern Univ, Feinberg Sch Med, Dept Biochem & Mol Genet, Chicago, IL 60208 USA.
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Northwestern Univ, Dept Mol Biosci, Dept Chem, Evanston, IL 60208 USA;Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA. Florida State Univ, Natl High Magnet Field Lab, Tallahassee, FL USA. (creator_code:org_t)
American Association for the Advancement of Science (AAAS), 2022
2022
English.
In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 375:6579, s. 411-
Related links:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Human biology is tightly linked to proteins, yet most measurements do not precisely determine alternatively spliced sequences or posttranslational modifications. Here, we present the primary structures of similar to 30,000 unique proteoforms, nearly 10 times more than in previous studies, expressed from 1690 human genes across 21 cell types and plasma from human blood and bone marrow. The results, compiled in the Blood Proteoform Atlas (BPA), indicate that proteoforms better describe protein-level biology and are more specific indicators of differentiation than their corresponding proteins, which are more broadly expressed across cell types. We demonstrate the potential for clinical application, by interrogating the BPA in the context of liver transplantation and identifying cell and proteoform signatures that distinguish normal graft function from acute rejection and other causes of graft dysfunction.

Subject headings

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

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