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  • Altay, ÖzlemKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Department of Clinical Microbiology, Dr Sami Ulus Training and Research Hospital, University of Health Sciences, Ankara, 06080 Turkey,University of Health Sciences,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH) (author)

Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-06-28
  • Wiley,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-310169
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-310169URI
  • https://doi.org/10.1002/advs.202101222DOI
  • https://research.chalmers.se/publication/524843URI
  • https://gup.ub.gu.se/publication/306329URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20220323
  • COVID-19 is associated with mitochondrial dysfunction and metabolic abnormalities, including the deficiencies in nicotinamide adenine dinucleotide (NAD+) and glutathione metabolism. Here it is investigated if administration of a mixture of combined metabolic activators (CMAs) consisting of glutathione and NAD+ precursors can restore metabolic function and thus aid the recovery of COVID-19 patients. CMAs include l-serine, N-acetyl-l-cysteine, nicotinamide riboside, and l-carnitine tartrate, salt form of l-carnitine. Placebo-controlled, open-label phase 2 study and double-blinded phase 3 clinical trials are conducted to investigate the time of symptom-free recovery on ambulatory patients using CMAs. The results of both studies show that the time to complete recovery is significantly shorter in the CMA group (6.6 vs 9.3 d) in phase 2 and (5.7 vs 9.2 d) in phase 3 trials compared to placebo group. A comprehensive analysis of the plasma metabolome and proteome reveals major metabolic changes. Plasma levels of proteins and metabolites associated with inflammation and antioxidant metabolism are significantly improved in patients treated with CMAs as compared to placebo. The results show that treating patients infected with COVID-19 with CMAs lead to a more rapid symptom-free recovery, suggesting a role for such a therapeutic regime in the treatment of infections leading to respiratory problems.

Subject headings and genre

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  • Arif, MuhammadKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:kth)u1vvaean (author)
  • Li, XiangyuKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:kth)u1h6x89c (author)
  • Yang, HongKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:kth)u150v7zg (author)
  • Aydın, M.Department of Infectious Diseases, Umraniye Training and Research Hospital, University of Health Sciences, Istanbul, 34766 Turkey,University of Health Sciences (author)
  • Alkurt, G.Genomic Laboratory (GLAB), Umraniye Training and Research Hospital, University of Health Sciences, Istanbul, 34766 Turkey,University of Health Sciences (author)
  • Kim, WoongheeKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:kth)u1nic2pk (author)
  • Akyol, D.Genomic Laboratory (GLAB), Umraniye Training and Research Hospital, University of Health Sciences, Istanbul, 34766 Turkey,University of Health Sciences (author)
  • Zhang, ChengKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, Henan, 450001 P. R. China,Zhengzhou University,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:cth)chengz (author)
  • Dinler-Doganay, G.Department of Molecular Biology and Genetics, Istanbul Technical University, Istanbul, 34469 Turkey,Istanbul Teknik Universitesi (ITÜ),Istanbul Technical University (ITÜ) (author)
  • Turkez, H.Department of Molecular Biology and Genetics, Istanbul Technical University, Istanbul, 34469 Turkey,Atatürk Üniversitesi,Atatürk University (author)
  • Shoaie, SaeedKTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, SE1 1UL UK,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH),King's College London(Swepub:cth)saeeds (author)
  • Nielsen, Jens B,1962Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, SE-41296 Sweden,Chalmers tekniska högskola,Chalmers University of Technology,Department of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital Gothenburg, Gothenburg, SE-41345 Sweden(Swepub:cth)nielsenj (author)
  • Borén, Jan,1963Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xborej (author)
  • Olmuscelik, O.Department of Internal Medicine, Istanbul Medipol University, Bagcılar, Istanbul, 34214 Turkey,Istanbul Medipol Universitesi (author)
  • Doganay, L.Department of Gastroenterology, Umraniye Training and Research Hospital, University of Health Sciences, Istanbul, 34766 Turkey,University of Health Sciences (author)
  • Uhlén, MathiasKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:kth)u1dulvmw (author)
  • Mardinoglu, AdilKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, SE1 1UL UK,King's College London,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:cth)adilm (author)
  • KTHScience for Life Laboratory, SciLifeLab (creator_code:org_t)

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