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Resveratrol-conjuga...
Resveratrol-conjugated poly-epsilon-caprolactone facilitates in vitro mineralization and in vivo bone regeneration
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- Li, Yan (author)
- Karolinska Institutet
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- Dånmark, Staffan (author)
- KTH,Fiber- och polymerteknologi
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- Edlund, Ulrica (author)
- KTH,Fiber- och polymerteknologi
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- Finne-Wistrand, Anna (author)
- KTH,Fiber- och polymerteknologi
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He, Xu (author)
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Norgard, Maria (author)
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Blomen, Eva (author)
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- Hultenby, Kjell (author)
- Karolinska Institutet
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- Andersson, Goran (author)
- Karolinska Institutet
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- Lindgren, Urban (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: ACTA BIOMATERIALIA. - : Elsevier BV. - 1742-7061 .- 1878-7568. ; 7:2, s. 751-758
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Incorporation of osteoinductive factors in a suitable scaffold is considered a promising strategy for generating osteogenic biomaterials. Resveratrol is a polyphenol found in parts of certain plants, including nuts, berries and grapes. It is known to increase DNA synthesis and alkaline phosphatase (ALP) activity in osteoblasts and to prevent femoral bone loss in ovariectomized (OVX) rats. In the present study resveratrol was coupled through a hydrolysable covalent bond with the carboxylic acid groups in porous poly-epsilon-caprolactone (PCL) surface grafted with acrylic acid (AA). The osteogenic effect of this new scaffold was evaluated in mesenchymal cell culture and in the rat calvarial defect model. We found that the incorporation of resveratrol caused increased ALP activity of rat bone marrow stromal cells and enhanced mineralization of the cell-scaffold composites in vitro. After 8 weeks the calvarial defects implanted with resveratrol-conjugated PCL displayed a higher X-ray density than the defects implanted with control PCL. Bone-like structures, positively immunostained for bone sialoprotein, were shown to be more extensively formed in the resveratrol-conjugated PCL These results show that incorporation of resveratrol into the AA-functionalized porous PCL scaffold led to a significant increase in osteogenesis. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Materialteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering (hsv//eng)
Keyword
- Resveratrol
- Biodegradable scaffolds
- Bone regeneration
- Vapor phase grafting
- Tissue engineering
- Bioengineering
- Bioteknik
- Materials science
- Teknisk materialvetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Li, Yan
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Dånmark, Staffan
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Edlund, Ulrica
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Finne-Wistrand, ...
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He, Xu
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Norgard, Maria
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show more...
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Blomen, Eva
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Hultenby, Kjell
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Andersson, Goran
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Lindgren, Urban
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show less...
- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Industrial Biote ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Materials Engine ...
- Articles in the publication
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ACTA BIOMATERIAL ...
- By the university
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Royal Institute of Technology
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Karolinska Institutet