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Safety evaluation o...
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Chireh, A.Karolinska Institutet
(author)
Safety evaluation of high-risk myocardial micro-biopsy in a swine model
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2021-11-23
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Springer Nature,2022
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-313197
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-313197URI
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https://doi.org/10.1007/s00380-021-01995-9DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:148168074URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20220607
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The objective of the study was to investigate the safety profile of high-risk micro-endomyocardial biopsy (micro-EMB) compared to conventional EMB in a large animal model. Twenty pigs were subjected to a maximum of 30 consecutive biopsies, including sampling from the free ventricular wall, with either micro-EMB (n = 10) or conventional EMB (n = 10). There were no major complications in the micro-EMB group (0/10), compared to six major complications in the EMB group (6/10; p = 0.003). Survival analysis further highlighted these differences (p = 0.004). There were significantly higher volumes of pericardial effusion in the EMB group (p = 0.01). The study shows a safety advantage of micro-EMB compared to standard EMB in the experimental high-risk circumstances investigated in this animal study. These results indicate enhanced possibilities to collect samples from sensitive areas by using the micro-EMB technique instead of standard EMB.
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Sandell, MikaelKTH,Mikro- och nanosystemteknik,Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; MedTechLabs, Solna, Sweden(Swepub:kth)u13uy6zj
(author)
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Grankvist, R.Karolinska Institutet
(author)
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Lövljung, V.
(author)
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al-Saadi, J.
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Arnberg, F.Karolinska Institutet
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Lundberg, J.Karolinska Institutet
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Settergren, M.Karolinska Institutet
(author)
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Holmin, S.Karolinska Institutet
(author)
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Karolinska InstitutetMikro- och nanosystemteknik
(creator_code:org_t)
Related titles
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In:Heart and Vessels: Springer Nature37:4, s. 697-7040910-83271615-2573
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