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Athero-occlusive Di...
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Matthews, Evan O.James Cook Univ, Coll Med & Dent, Queensland Res Ctr Peripheral Vasc Dis, Townsville, Qld 4811, Australia.
(author)
Athero-occlusive Disease Appears to be Associated with Slower Abdominal Aortic Aneurysm Growth : An Exploratory Analysis of the TEDY Trial
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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Elsevier BV,2022
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Numbers
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LIBRIS-ID:oai:DiVA.org:kth-313309
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-313309URI
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https://doi.org/10.1016/j.ejvs.2021.12.038DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20220602
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Objective: The role of atherosclerosis in abdominal aortic aneurysm (AAA) pathogenesis is controversial. The aim of this study was to compare AAA growth in patients who did and did not have concurrent athero-occlusive disease (AOD). Methods: Patients with an AAA measuring 35 - 49 mm in maximum diameter were recruited as part of the TElmisartan in the management of abdominal aortic aneurysm (TEDY) trial. TEDY participants who had infrarenal aortic volume and orthogonal diameter assessed by computed tomography at entry and at least one other time point during the trial (12 and/or 24 months) were included. AOD was defined by prior diagnoses of coronary heart disease, stroke, or peripheral arterial disease or an ankle brachial pressure index < 0.90. The increase in AAA volume and diameter from entry for participants who did and did not have AOD was assessed using linear mixed effects models; 131 of the 210 participants recruited to TEDY were included. Results: In an unadjusted analysis, the mean (95% confidence interval) annual increases in AAA volume and diameter for participants with AOD were 3.26 (0.82 - 5.70) cm(3) and 0.70 (0.19 - 1.22) mm slower than those without AOD, p = .008 and.007 respectively. The association between AOD and significantly slower AAA growth was maintained after adjusting for risk factors and medications, significantly unequally distributed between participants with and without an AOD diagnosis. Conclusion: In an exploratory analysis of a selective cohort from the TEDY trial, AOD was associated with slower AAA growth. Validation of these findings in other cohorts is needed.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Moxon, Joseph, VJames Cook Univ, Coll Med & Dent, Queensland Res Ctr Peripheral Vasc Dis, Townsville, Qld 4811, Australia.;James Cook Univ, Ctr Mol Therapeut, Australian Inst Trop Hlth & Med, Townsville, Qld, Australia.
(author)
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Singh, Tejas P.James Cook Univ, Coll Med & Dent, Queensland Res Ctr Peripheral Vasc Dis, Townsville, Qld 4811, Australia.;Townsville Univ Hosp, Dept Vasc & Endovasc Surg, Townsville, Qld, Australia.
(author)
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Thanigaimani, ShivshankarJames Cook Univ, Coll Med & Dent, Queensland Res Ctr Peripheral Vasc Dis, Townsville, Qld 4811, Australia.;James Cook Univ, Ctr Mol Therapeut, Australian Inst Trop Hlth & Med, Townsville, Qld, Australia.
(author)
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Jones, Rhondda E.James Cook Univ, Coll Med & Dent, Queensland Res Ctr Peripheral Vasc Dis, Townsville, Qld 4811, Australia.;James Cook Univ, Ctr Mol Therapeut, Australian Inst Trop Hlth & Med, Townsville, Qld, Australia.
(author)
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Gasser, Thomas C.KTH,Hållfasthetslära(Swepub:kth)u1dvxi4s
(author)
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Fitridge, RobertUniv Adelaide, Discipline Surg, Adelaide, SA, Australia.;Royal Adelaide Hosp, Dept Vasc & Endovasc Surg, Cent Adelaide Local Hlth Network, Adelaide, SA, Australia.;Queen Elizabeth Hosp, Div Surg, Woodville South, SA, Australia.
(author)
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Lindeman, Jan H. N.Leiden Univ, Dept Vasc Surg, Med Ctr, Leiden, Netherlands.
(author)
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Dalman, Ronald L.Stanford Univ, Sch Med, Dept Surg, Stanford, CA 94305 USA.;Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA USA.
(author)
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Golledge, JonathanJames Cook Univ, Coll Med & Dent, Queensland Res Ctr Peripheral Vasc Dis, Townsville, Qld 4811, Australia.;James Cook Univ, Ctr Mol Therapeut, Australian Inst Trop Hlth & Med, Townsville, Qld, Australia.;Townsville Univ Hosp, Dept Vasc & Endovasc Surg, Townsville, Qld, Australia.
(author)
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James Cook Univ, Coll Med & Dent, Queensland Res Ctr Peripheral Vasc Dis, Townsville, Qld 4811, Australia.James Cook Univ, Coll Med & Dent, Queensland Res Ctr Peripheral Vasc Dis, Townsville, Qld 4811, Australia.;James Cook Univ, Ctr Mol Therapeut, Australian Inst Trop Hlth & Med, Townsville, Qld, Australia.
(creator_code:org_t)
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In:European Journal of Vascular and Endovascular Surgery: Elsevier BV63:4, s. 632-6401078-58841532-2165
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Moxon, Joseph, V
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