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The Wittig bioconju...
The Wittig bioconjugation of maleimide derived, water soluble phosphonium ylides to aldehyde-tagged proteins
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Hartmann, R. W. (author)
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Pijnappel, M. (author)
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- Nilvebrant, Johan, 1982- (author)
- KTH,Albanova VinnExcellence Center for Protein Technology, ProNova,Proteinteknologi
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Helgudottir, H. R. (author)
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Asbjarnarson, A. (author)
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Traustadottir, G. A. (author)
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Gudjonsson, T. (author)
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- Nygren, Per-Åke, 1961- (author)
- KTH,Albanova VinnExcellence Center for Protein Technology, ProNova,Proteinvetenskap
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Lehmann, F. (author)
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Odell, L. R. (author)
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(creator_code:org_t)
- 2021
- 2021
- English.
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In: Organic and biomolecular chemistry. - : Royal Society of Chemistry (RSC). - 1477-0520 .- 1477-0539. ; 19:47, s. 10417-10423
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https://doi.org/10.1...
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https://pubs.rsc.org...
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Abstract
Subject headings
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- Herein we disclose the transformation of maleimides into water-soluble tris(2-carboxyethyl)phosphonium ylides and their subsequent application in the bioconjugation of protein- and peptide-linked aldehydes. The new entry into Wittig bioconjugate chemistry proceeds under mild conditions and relies on highly water soluble reagents, which are likely already part of most biochemists' inventory.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
Keyword
- Proteins
- Bio-conjugation
- Bioconjugates
- Condition
- Maleimides
- Soluble reagents
- Tagged proteins
- Watersoluble
- Aldehydes
- maleimide
- maleimide derivative
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hartmann, R. W.
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Pijnappel, M.
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Nilvebrant, Joha ...
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Helgudottir, H. ...
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Asbjarnarson, A.
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Traustadottir, G ...
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show more...
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Gudjonsson, T.
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Nygren, Per-Åke, ...
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Lehmann, F.
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Odell, L. R.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Organic Chemistr ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomedical Labor ...
- Articles in the publication
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Organic and biom ...
- By the university
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Royal Institute of Technology