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- Hartmann, R. W. (author)
The Wittig bioconjugation of maleimide derived, water soluble phosphonium ylides to aldehyde-tagged proteins
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2021
- Royal Society of Chemistry (RSC),2021
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:kth-313842
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-313842URI
- https://doi.org/10.1039/d1ob01155cDOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- QC 20220613
- Herein we disclose the transformation of maleimides into water-soluble tris(2-carboxyethyl)phosphonium ylides and their subsequent application in the bioconjugation of protein- and peptide-linked aldehydes. The new entry into Wittig bioconjugate chemistry proceeds under mild conditions and relies on highly water soluble reagents, which are likely already part of most biochemists' inventory.
Subject headings and genre
- NATURVETENSKAP Kemi Organisk kemi hsv//swe
- NATURAL SCIENCES Chemical Sciences Organic Chemistry hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Biomedicinsk laboratorievetenskap/teknologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Medical Biotechnology Biomedical Laboratory Science/Technology hsv//eng
- Proteins
- Bio-conjugation
- Bioconjugates
- Condition
- Maleimides
- Soluble reagents
- Tagged proteins
- Watersoluble
- Aldehydes
- maleimide
- maleimide derivative
Added entries (persons, corporate bodies, meetings, titles ...)
- Pijnappel, M. (author)
- Nilvebrant, Johan,1982-KTH,Albanova VinnExcellence Center for Protein Technology, ProNova,Proteinteknologi(Swepub:kth)u17j1dcn (author)
- Helgudottir, H. R. (author)
- Asbjarnarson, A. (author)
- Traustadottir, G. A. (author)
- Gudjonsson, T. (author)
- Nygren, Per-Åke,1961-KTH,Albanova VinnExcellence Center for Protein Technology, ProNova,Proteinvetenskap(Swepub:kth)u1zhverl (author)
- Lehmann, F. (author)
- Odell, L. R. (author)
- KTHAlbanova VinnExcellence Center for Protein Technology, ProNova (creator_code:org_t)
Related titles
- In:Organic and biomolecular chemistry: Royal Society of Chemistry (RSC)19:47, s. 10417-104231477-05201477-0539
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