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New Views of Old Proteins : Clarifying the Enigmatic Proteome

Burnum-Johnson, Kristin E. (author)
Pacific Northwest Natl Lab, Environm Mol Sci Lab, Richland, WA 99354 USA.
Conrads, Thomas P. (author)
Inova Hlth Syst, Inova Womens Serv Line, Falls Church, VA USA.
Drake, Richard R. (author)
Med Univ South Carolina, Cell & Mol Pharmacol & Expt Therapeut, Charleston, SC USA.
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Herr, Amy E. (author)
Univ Calif Berkeley, Dept Bioengn, Berkeley, CA USA.
Iyengar, Ravi (author)
Icahn Sch Med Mt Sinai, Dept Pharmacol & Syst Therapeut, New York, NY USA.
Kelly, Ryan T. (author)
Brigham Young Univ, Dept Chem & Biochem, Provo, UT USA.
Lundberg, Emma (author)
KTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab
MacCoss, Michael J. (author)
Univ Washington, Dept Genome Sci, Seattle, WA USA.
Naba, Alexandra (author)
Univ Illinois, Dept Physiol & Biophys, Chicago, IL USA.
Nolan, Garry P. (author)
Stanford Univ, Dept Pathol, Stanford, CA USA.
Pevzner, Pavel A. (author)
Univ Calif San Diego, Dept Comp Sci & Engn, San Diego, CA USA.
Rodland, Karin D. (author)
Pacific Northwest Natl Lab, Biol Sci Div, Richland, WA USA.
Sechi, Salvatore (author)
NIDDKD, NIH, Bethesda, MD USA.
Slavov, Nikolai (author)
Northeastern Univ, Dept Bioengn, Boston, MA USA.
Spraggins, Jeffrey M. (author)
Vanderbilt Univ, Mass Spectrometry Res Ctr, Dept Cell & Dev Biol, Nashville, TN USA.
Van Eyk, Jennifer E. (author)
Cedars Sinai Med Ctr, Adv Clin Biosyst Inst, Dept Biomed Sci, Los Angeles, CA USA.
Vidal, Marc (author)
Harvard Univ, Dept Genet, Cambridge, MA USA.
Vogel, Christine (author)
NYU, Ctr Genom & Syst Biol, New York, NY USA.
Walt, David R. (author)
Harvard Univ, Brigham & Womens Hosp, Harvard Med Sch, Dept Pathol,Wyss Inst, Boston, MA USA.
Kelleher, Neil L. (author)
Northwestern Univ, Dept Chem, Evanston, IL 60208 USA.
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Pacific Northwest Natl Lab, Environm Mol Sci Lab, Richland, WA 99354 USA Inova Hlth Syst, Inova Womens Serv Line, Falls Church, VA USA. (creator_code:org_t)
Elsevier BV, 2022
2022
English.
In: Molecular & Cellular Proteomics. - : Elsevier BV. - 1535-9476 .- 1535-9484. ; 21:7
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide a >10 years of projection for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we describe a next generation of approaches to define, quantify, and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade.

Subject headings

NATURVETENSKAP  -- Biologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences (hsv//eng)

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