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Conformational Effe...
Conformational Effects Induced by Guest Encapsulation in an Enantiopure Water-Soluble Cryptophane
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Bouchet, Aude (author)
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Brotin, Thierry (author)
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- Linares, Mathieu (author)
- KTH,Teoretisk kemi
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- Ågren, Hans (author)
- KTH,Teoretisk kemi
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Cavagnat, Dominique (author)
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Buffeteau, Thierry (author)
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(creator_code:org_t)
- 2011-01-26
- 2011
- English.
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In: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 76:5, s. 1372-1383
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- A new water-soluble cryptophane 1 derivative (penta-hydroxyl cryptophane-A) has been synthesized from cryptophanol-A and the chiroptical properties of its two enantiomers M M-1 and P P-1 have been studied by polarimetry, electronic circular dichroism (ECD), and vibrational circular dichroism (VCD). Cryptophane 1 shows specific circular dichroism responses upon complexation that depend on the size of the guest and on the nature of the counterion (Li+, Na+, K+, Cs+) present in the solution. In LiOH and NaOH solutions, chiroptical changes induced by the encapsulation of guests and by the presence of cations in the vicinity of hosts can be interpreted from molecular dynamics (MD) and ab initio calculations by subtle conformational changes of the bridges. In KOH solution, the exchange dynamics is dependent on the size of the guest molecules, whereas in CsOH solution no encapsulation effect is observed whatever the size of the guest molecule. This last behavior comes from the fact that host 1 exhibits a very high affinity for cesium cations.
Subject headings
- NATURVETENSKAP -- Kemi -- Teoretisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Theoretical Chemistry (hsv//eng)
Keyword
- VIBRATIONAL CIRCULAR-DICHROISM; ATOM FORCE-FIELD; CHIROPTICAL PROPERTIES; COMPLEXATION DYNAMICS; HYPERPOLARIZED XENON; MAGNETIC-RESONANCE; INCLUSION COMPLEX; ORGANIC SOLUTION; NMR; MOLECULES
- Theoretical chemistry
- Teoretisk kemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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