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  • Zeybel, M.Koc Universitesi,Koç University,Nottingham University Hospitals NHS Trust,University Of Nottingham (author)

Multiomics Analysis Reveals the Impact of Microbiota on Host Metabolism in Hepatic Steatosis

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-02-07
  • Wiley,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-320546
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-320546URI
  • https://doi.org/10.1002/advs.202104373DOI
  • https://research.chalmers.se/publication/528722URI
  • https://gup.ub.gu.se/publication/314901URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20221028
  • Metabolic dysfunction-associated fatty liver disease (MAFLD) is a complex disease involving alterations in multiple biological processes regulated by the interactions between obesity, genetic background, and environmental factors including the microbiome. To decipher hepatic steatosis (HS) pathogenesis by excluding critical confounding factors including genetic variants and diabetes, 56 heterogenous MAFLD patients are characterized by generating multiomics data including oral and gut metagenomics as well as plasma metabolomics and inflammatory proteomics data. The dysbiosis in the oral and gut microbiome is explored and the host–microbiome interactions based on global metabolic and inflammatory processes are revealed. These multiomics data are integrated using the biological network and HS's key features are identified using multiomics data. HS is finally predicted using these key features and findings are validated in a follow-up cohort, where 22 subjects with varying degree of HS are characterized.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Arif, MuhammadKTH,Systembiologi,Science for Life Laboratory, SciLifeLab,Laboratory of Cardiovascular Physiology and Tissue Injury and Section on Fibrotic Disorders, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, 20852, MD, United States,National Institute on Alcohol Abuse and Alcoholism,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:kth)u1vvaean (author)
  • Li, XiangyuKTH,Systembiologi,Science for Life Laboratory, SciLifeLab,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:kth)u1h6x89c (author)
  • Altay, ÖzlemKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:kth)u1g32ner (author)
  • Yang, HongKTH,Science for Life Laboratory, SciLifeLab,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:kth)u150v7zg (author)
  • Shi, MengnanKTH,Science for Life Laboratory, SciLifeLab,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:kth)u1vcf12k (author)
  • Akyildiz, M.Koc Universitesi,Koç University (author)
  • Saglam, B.Koc Universitesi,Koç University (author)
  • Gonenli, M. G.Koc Universitesi,Koç University (author)
  • Yigit, B.Koc Universitesi,Koç University (author)
  • Ulukan, B.Koc Universitesi,Koç University (author)
  • Ural, D.Koc Universitesi,Koç University (author)
  • Shoaie, SaeedKTH,Science for Life Laboratory, SciLifeLab,Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, SE1 9RT, United Kingdom,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH),King's College London(Swepub:cth)saeeds (author)
  • Turkez, H.Atatürk Üniversitesi,Atatürk University (author)
  • Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj (author)
  • Zhang, ChengKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Henan Province, Zhengzhou, 450001, China,Zhengzhou University,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:cth)chengz (author)
  • Uhlén, MathiasKTH,Science for Life Laboratory, SciLifeLab,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:kth)u1dulvmw (author)
  • Borén, Jan,1963Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xborej (author)
  • Mardinoglu, AdilKTH,Science for Life Laboratory, SciLifeLab,King's College London,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:cth)adilm (author)
  • Koc UniversitesiNottingham University Hospitals NHS Trust (creator_code:org_t)

Related titles

  • In:Advanced Science: Wiley9:11, s. 2104373-2198-3844

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