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Search: onr:"swepub:oai:DiVA.org:kth-322355" > Comparative serum p...

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007188naa a2200589 4500
001oai:DiVA.org:kth-322355
003SwePub
008221212s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3223552 URI
0247 a https://doi.org/10.1038/s41398-022-02228-x2 DOI
040 a (SwePub)kth
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Kohshour, Mojtaba Orakiu Ludwig Maximilians Univ Munchen, Inst Psychiat Phen & Genom IPPG, Univ Hosp, Munich, Germany.;Ahvaz Jundishapur Univ Med Sci, Fac Med, Dept Immunol, Ahvaz, Iran.4 aut
2451 0a Comparative serum proteomic analysis of a selected protein panel in individuals with schizophrenia and bipolar disorder and the impact of genetic risk burden on serum proteomic profiles
264 c 2022-11-09
264 1b Springer Nature,c 2022
338 a print2 rdacarrier
500 a QC 20221212
520 a The diagnostic criteria for schizophrenia (SCZ) and bipolar disorder (BD) are based on clinical assessments of symptoms. In this pilot study, we applied high-throughput antibody-based protein profiling to serum samples of healthy controls and individuals with SCZ and BD with the aim of identifying differentially expressed proteins in these disorders. Moreover, we explored the influence of polygenic burden for SCZ and BD on the serum levels of these proteins. Serum samples from 113 individuals with SCZ and 125 with BD from the PsyCourse Study and from 44 healthy controls were analyzed by using a set of 155 antibodies in an antibody-based assay targeting a selected panel of 95 proteins. For the cases, genotyping and imputation were conducted for DNA samples and SCZ and BD polygenic risk scores (PRS) were calculated. Univariate linear and logistic models were used for association analyses. The comparison between SCZ and BD revealed two serum proteins that were significantly elevated in BD after multiple testing adjustment: "complement C9" and "Interleukin 1 Receptor Accessory Protein". Moreover, the first principal component of variance in the proteomics dataset differed significantly between SCZ and BD. After multiple testing correction, SCZ-PRS, BD-PRS, and SCZ-vs-BD-PRS were not significantly associated with the levels of the individual proteins or the values of the proteome principal components indicating no detectable genetic effects. Overall, our findings contribute to the evidence suggesting that the analysis of circulating proteins could lead to the identification of distinctive biomarkers for SCZ and BD. Our investigation warrants replication in large-scale studies to confirm these findings.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
7001 a Kannaiyan, Nirmal R.u Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany.4 aut
7001 a Jernbom Falk, Augustu KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1db8k5t
7001 a Papiol, Sergiu Ludwig Maximilians Univ Munchen, Inst Psychiat Phen & Genom IPPG, Univ Hosp, Munich, Germany.;Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany.4 aut
7001 a Heilbronner, Ursu Ludwig Maximilians Univ Munchen, Inst Psychiat Phen & Genom IPPG, Univ Hosp, Munich, Germany.4 aut
7001 a Budde, Monikau Ludwig Maximilians Univ Munchen, Inst Psychiat Phen & Genom IPPG, Univ Hosp, Munich, Germany.4 aut
7001 a Kalman, Janos L.u Ludwig Maximilians Univ Munchen, Inst Psychiat Phen & Genom IPPG, Univ Hosp, Munich, Germany.;Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany.;Max Planck Inst Psychiat, Int Max Planck Res Sch Translat Psychiat IMPRS TP, Munich, Germany.4 aut
7001 a Schulte, Eva C.u Ludwig Maximilians Univ Munchen, Inst Psychiat Phen & Genom IPPG, Univ Hosp, Munich, Germany.;Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany.4 aut
7001 a Rietschel, Marcellau Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Mannheim, Germany.4 aut
7001 a Witt, Stephanieu Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Mannheim, Germany.4 aut
7001 a Forstner, Andreas J.u Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany.;Univ Hosp Bonn, Bonn, Germany.4 aut
7001 a Heilmann-Heimbach, Stefanieu Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany.;Univ Hosp Bonn, Bonn, Germany.4 aut
7001 a Nöthen, Markus M.u Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany.;Univ Hosp Bonn, Bonn, Germany.4 aut
7001 a Spitzer, Carstenu Univ Med Ctr Rostock, Dept Psychosomat Med & Psychotherapy, Rostock, Germany.4 aut
7001 a Malchow, Berendu Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany.4 aut
7001 a Müller, Thorstenu Ludwig Maximilians Univ Munchen, Inst Psychiat Phen & Genom IPPG, Univ Hosp, Munich, Germany.4 aut
7001 a Wiltfang, Jensu Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany.;German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany.;Univ Aveiro, Med Sci Dept, iBiMED, Aveiro, Portugal.4 aut
7001 a Falkai, Peteru Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany.4 aut
7001 a Schmitt, Andreau Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany.;Univ Sao Paulo, Inst Psychiat, Lab Neurosci LIM27, Sao Paulo, SP, Brazil.4 aut
7001 a Rossner, Moritz J.u Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany.4 aut
7001 a Nilsson, Peteru KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik4 aut0 (Swepub:kth)u1ws88sk
7001 a Schulze, Thomas G.u Ludwig Maximilians Univ Munchen, Inst Psychiat Phen & Genom IPPG, Univ Hosp, Munich, Germany.;SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, Syracuse, NY 13210 USA.;Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA.4 aut
7102 a Ludwig Maximilians Univ Munchen, Inst Psychiat Phen & Genom IPPG, Univ Hosp, Munich, Germany.;Ahvaz Jundishapur Univ Med Sci, Fac Med, Dept Immunol, Ahvaz, Iran.b Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany.4 org
7730 t Translational Psychiatryd : Springer Natureg 12:1q 12:1x 2158-3188
8564 u https://doi.org/10.1038/s41398-022-02228-xy Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-322355
8564 8u https://doi.org/10.1038/s41398-022-02228-x

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