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Cell transcriptomic...
Cell transcriptomic atlas of the non-human primate Macaca fascicularis
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Han, L. (author)
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Wei, X. (author)
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Liu, C. (author)
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Volpe, G. (author)
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Zhuang, Z. (author)
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Zou, X. (author)
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Wang, Z. (author)
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Pan, T. (author)
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Yuan, Y. (author)
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Zhang, X. (author)
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Fan, P. (author)
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Guo, P. (author)
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Lai, Y. (author)
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Lei, Y. (author)
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Liu, X. (author)
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Yu, F. (author)
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Shangguan, S. (author)
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Lai, G. (author)
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Deng, Q. (author)
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Liu, Y. (author)
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Wu, L. (author)
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Shi, Q. (author)
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Yu, H. (author)
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Huang, Y. (author)
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Cheng, M. (author)
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Xu, J. (author)
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Wang, M. (author)
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Wang, C. (author)
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Zhang, Y. (author)
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Xie, D. (author)
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Yang, Y. (author)
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Yu, Y. (author)
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Zheng, H. (author)
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Wei, Y. (author)
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Huang, F. (author)
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Lei, J. (author)
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Huang, W. (author)
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Zhu, Z. (author)
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Lu, H. (author)
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Wang, B. (author)
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Chen, F. (author)
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Yang, T. (author)
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Du, W. (author)
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Chen, J. (author)
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Xu, S. (author)
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An, J. (author)
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Ward, C. (author)
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Pei, Z. (author)
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Wong, C. -W (author)
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Zhang, H. (author)
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Liu, M. (author)
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Qin, B. (author)
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Schambach, A. (author)
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Isern, J. (author)
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Feng, L. (author)
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Guo, X. (author)
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Liu, Z. (author)
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Sun, Q. (author)
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Maxwell, P. H. (author)
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Barker, N. (author)
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Muñoz-Cánoves, P. (author)
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Gu, Y. (author)
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- Mulder, Jan (author)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap
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- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi
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Tan, T. (author)
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Liu, S. (author)
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Yang, H. (author)
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Wang, J. (author)
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Hou, Y. (author)
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Xu, X. (author)
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Esteban, M. A. (author)
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Liu, L. (author)
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(creator_code:org_t)
- 2022-04-13
- 2022
- English.
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In: Nature. - : Springer Nature. - 0028-0836 .- 1476-4687. ; 604:7907, s. 723-731
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell–cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Wnt protein
- transcriptome
- cell
- genetic analysis
- phylogenetics
- primate
- adult
- animal cell
- animal experiment
- animal tissue
- Article
- cell interaction
- cell isolation
- cell transcriptomic atlas
- cellular
- subcellular and molecular biological phenomena and functions
- controlled study
- female
- genetic disorder
- Macaca fascicularis
- male
- mouse
- nonhuman
- phylogeny
- RNA sequencing
- single cell RNA seq
- single nucleus RNA sequencing
- species comparison
- virus infection
- Wnt signaling
- animal
- genetics
- virus
- Animals
- Primates
- Viruses
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
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Nature
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
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Han, L.
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Wei, X.
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Liu, C.
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Volpe, G.
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Zhuang, Z.
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Zou, X.
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show more...
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Wang, Z.
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Pan, T.
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Yuan, Y.
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Zhang, X.
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Fan, P.
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Guo, P.
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Lai, Y.
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Lei, Y.
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Liu, X.
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Yu, F.
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Shangguan, S.
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Lai, G.
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Deng, Q.
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Liu, Y.
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Wu, L.
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Shi, Q.
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Yu, H.
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Huang, Y.
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Cheng, M.
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Xu, J.
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Wang, M.
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Wang, C.
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Zhang, Y.
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Xie, D.
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Yang, Y.
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Yu, Y.
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Zheng, H.
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Wei, Y.
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Huang, F.
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Lei, J.
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Huang, W.
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Zhu, Z.
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Lu, H.
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Wang, B.
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Chen, F.
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Yang, T.
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Du, W.
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Chen, J.
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Xu, S.
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An, J.
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Ward, C.
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Pei, Z.
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Wong, C. -W
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Zhang, H.
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Liu, M.
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Qin, B.
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Schambach, A.
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Isern, J.
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Feng, L.
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Guo, X.
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Liu, Z.
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Sun, Q.
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Maxwell, P. H.
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Barker, N.
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Muñoz-Cánoves, P ...
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Gu, Y.
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Mulder, Jan
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Uhlén, Mathias
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Tan, T.
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Liu, S.
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Yang, H.
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Wang, J.
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Hou, Y.
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Xu, X.
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Esteban, M. A.
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Liu, L.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Nature
- By the university
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Royal Institute of Technology
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Karolinska Institutet