Search: onr:"swepub:oai:DiVA.org:kth-322985" >
Cell transcriptomic...
Cell transcriptomic atlas of the non-human primate Macaca fascicularis
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-04-13
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Springer Nature,2022
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-322985
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-322985URI
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https://doi.org/10.1038/s41586-022-04587-3DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149336062URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20230116
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Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell–cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.
Subject headings and genre
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NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
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NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
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Wnt protein
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transcriptome
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cell
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genetic analysis
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phylogenetics
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primate
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adult
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animal cell
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animal experiment
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animal tissue
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Article
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cell interaction
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cell isolation
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cell transcriptomic atlas
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cellular
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subcellular and molecular biological phenomena and functions
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controlled study
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female
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genetic disorder
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Macaca fascicularis
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male
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mouse
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nonhuman
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phylogeny
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RNA sequencing
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single cell RNA seq
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single nucleus RNA sequencing
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species comparison
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virus infection
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Wnt signaling
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animal
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genetics
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virus
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Animals
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Primates
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Viruses
Added entries (persons, corporate bodies, meetings, titles ...)
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Wei, X.
(author)
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Liu, C.
(author)
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Volpe, G.
(author)
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Zhuang, Z.
(author)
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Zou, X.
(author)
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Wang, Z.
(author)
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Pan, T.
(author)
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Yuan, Y.
(author)
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Zhang, X.
(author)
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Fan, P.
(author)
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Guo, P.
(author)
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Lai, Y.
(author)
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Lei, Y.
(author)
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Liu, X.
(author)
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Yu, F.
(author)
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Shangguan, S.
(author)
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Lai, G.
(author)
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Deng, Q.
(author)
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Liu, Y.
(author)
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Wu, L.
(author)
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Shi, Q.
(author)
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Yu, H.
(author)
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Huang, Y.
(author)
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Cheng, M.
(author)
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Xu, J.
(author)
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Wang, M.
(author)
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Wang, C.
(author)
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Zhang, Y.
(author)
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Xie, D.
(author)
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Yang, Y.
(author)
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Yu, Y.
(author)
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Zheng, H.
(author)
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Wei, Y.
(author)
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Huang, F.
(author)
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Lei, J.
(author)
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Huang, W.
(author)
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Zhu, Z.
(author)
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Lu, H.
(author)
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Wang, B.
(author)
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Chen, F.
(author)
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Yang, T.
(author)
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Du, W.
(author)
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Chen, J.
(author)
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Xu, S.
(author)
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An, J.
(author)
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Ward, C.
(author)
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Pei, Z.
(author)
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Wong, C. -W
(author)
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Zhang, H.
(author)
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Liu, M.
(author)
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Qin, B.
(author)
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Schambach, A.
(author)
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Isern, J.
(author)
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Feng, L.
(author)
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Guo, X.
(author)
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Liu, Z.
(author)
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Sun, Q.
(author)
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Maxwell, P. H.
(author)
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Barker, N.
(author)
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Muñoz-Cánoves, P.
(author)
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Gu, Y.
(author)
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Mulder, JanKarolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap(Swepub:kth)u14o2jvk
(author)
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Uhlén, MathiasKTH,Science for Life Laboratory, SciLifeLab,Systembiologi(Swepub:kth)u1dulvmw
(author)
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Tan, T.
(author)
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Liu, S.
(author)
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Yang, H.
(author)
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Wang, J.
(author)
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Hou, Y.
(author)
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Xu, X.
(author)
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Esteban, M. A.
(author)
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Liu, L.
(author)
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KTHScience for Life Laboratory, SciLifeLab
(creator_code:org_t)
Related titles
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In:Nature: Springer Nature604:7907, s. 723-7310028-08361476-4687
Internet link
Find in a library
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Nature
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To the university's database
- By the author/editor
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Han, L.
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Wei, X.
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Liu, C.
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Volpe, G.
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Zhuang, Z.
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Zou, X.
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show more...
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Wang, Z.
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Pan, T.
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Yuan, Y.
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Zhang, X.
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Fan, P.
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Guo, P.
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Lai, Y.
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Lei, Y.
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Liu, X.
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Yu, F.
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Shangguan, S.
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Lai, G.
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Deng, Q.
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Liu, Y.
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Wu, L.
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Shi, Q.
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Yu, H.
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Huang, Y.
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Cheng, M.
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Xu, J.
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Wang, M.
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Wang, C.
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Zhang, Y.
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Xie, D.
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Yang, Y.
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Yu, Y.
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Zheng, H.
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Wei, Y.
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Huang, F.
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Lei, J.
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Huang, W.
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Zhu, Z.
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Lu, H.
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Wang, B.
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Chen, F.
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Yang, T.
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Du, W.
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Chen, J.
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Xu, S.
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An, J.
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Ward, C.
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Pei, Z.
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Wong, C. -W
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Zhang, H.
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Liu, M.
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Qin, B.
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Schambach, A.
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Isern, J.
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Feng, L.
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Guo, X.
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Liu, Z.
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Sun, Q.
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Maxwell, P. H.
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Barker, N.
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Muñoz-Cánoves, P ...
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Gu, Y.
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Mulder, Jan
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Uhlén, Mathias
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Tan, T.
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Liu, S.
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Yang, H.
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Wang, J.
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Hou, Y.
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Xu, X.
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Esteban, M. A.
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Liu, L.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Nature
- By the university
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Royal Institute of Technology
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Karolinska Institutet