onr:"swepub:oai:DiVA.org:kth-323277"
Search: onr:"swepub:oai:DiVA.org:kth-323277" > Developments in the...
- 1 of 1
- Previous record
- Next record
- To hitlist
Developments in the use of microfluidics in synthetic biology
-
- Damiati, Laila A. (author)
- Department of Biology, College of Science, University of Jeddah, Jeddah, Saudi Arabia;Centre for the Cellular Microenvironment, University of Glasgow, Glasgow, United Kingdom
-
- Damiati, Safa A. (author)
- Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia
-
- Damiati, Samar (author)
- KTH,Science for Life Laboratory, SciLifeLab,Nanobioteknologi,Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
- (creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
- In: New Frontiers and Applications of Synthetic Biology. - : Elsevier BV. ; , s. 423-435
- Book chapter (other academic/artistic)
Abstract
Subject headings
Close
- Biomimetics aims to copy and imitate natural elements and systems in a simpler form to overcome the limitations of complex biological elements and systems. The construction of biomimetic platforms to investigate physiological conditions requires an understanding of the native structure of cells and tissues and their interactions. Thus synthetic biology effectively connects biology and engineering. The engineering of custom cells/organs involves the construction of seminatural models that either perform existing functions in a modified manner or perform functions that do not exist naturally. In addition to providing an understanding of biological approaches, artificial models allow the mimicking of human physiology and diseases, facilitating the discovery of new drugs. Microfluidics is one of the most advanced technologies that allow the studying, mimicking, and manipulation of biological behaviors. Microfluidic devices are miniaturized devices that are functionally integrated on a single platform. The continuous development of microfluidic technology has led to the generation of artificial cells/organs that are based on in vivo mimetic models. Hence, it offers promising approaches for drug analysis, investigation of diseases and toxicity pathways, and construction of artificial models and even synthetic cell/organ chassis. This chapter presents microfluidic innovations for cell-like and organ-like architectures that were developed to simplify the complex networks of cells and organs. The merging of synthetic biology and microfluidics has led to the successful generation of artificial cells and organ-on-a-chip models. These biomimetic microfluidic environments have reduced the technical difficulties that acted as obstacles to studying cellular biology, have allowed the investigation of cell-cell, cell-tissue, and organ-like interfaces, and have aided the discovery of new therapeutic agents.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Artificial cells
- Biomimicry
- Drug carriers
- Microbes-on-chip
- Microfluidics
- Organ-on-a-chip
Publication and Content Type
- vet (subject category)
- kap (subject category)
Find in a library
- New Frontiers and Applications of Synthetic Biology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Damiati, Laila A ...
- Damiati, Safa A.
- Damiati, Samar
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Biochemistry and ...
- Articles in the publication
- New Frontiers an ...
- By the university
- Royal Institute of Technology
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
