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  • Frede, AnnikaKarolinska Inst, Dept Med Solna, Div Immunol & Allergy, Stockholm, Sweden.;Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Ctr Mol Med, Stockholm, Sweden. (author)

B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier BV,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-324408
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-324408URI
  • https://doi.org/10.1016/j.immuni.2022.11.002DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151743541URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20230301
  • Therapeutic promotion of intestinal regeneration holds great promise, but defining the cellular mechanisms that influence tissue regeneration remains an unmet challenge. To gain insight into the process of mucosal healing, we longitudinally examined the immune cell composition during intestinal damage and regeneration. B cells were the dominant cell type in the healing colon, and single-cell RNA sequencing (scRNA-seq) re-vealed expansion of an IFN-induced B cell subset during experimental mucosal healing that predominantly located in damaged areas and associated with colitis severity. B cell depletion accelerated recovery upon injury, decreased epithelial ulceration, and enhanced gene expression programs associated with tissue re-modeling. scRNA-seq from the epithelial and stromal compartments combined with spatial transcriptomics and multiplex immunostaining showed that B cells decreased interactions between stromal and epithelial cells during mucosal healing. Activated B cells disrupted the epithelial-stromal cross talk required for orga-noid survival. Thus, B cell expansion during injury impairs epithelial-stromal cell interactions required for mucosal healing, with implications for the treatment of IBD.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Czarnewski, PauloKarolinska Inst, Dept Med Solna, Div Immunol & Allergy, Stockholm, Sweden.;Univ Hosp, Stockholm, Sweden. (author)
  • Monasterio, GustavoKarolinska Inst, Dept Med Solna, Div Immunol & Allergy, Stockholm, Sweden.;Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Ctr Mol Med, Stockholm, Sweden. (author)
  • Tripathi, Kumar P.Karolinska Inst, Dept Med Solna, Div Immunol & Allergy, Stockholm, Sweden.;Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Ctr Mol Med, Stockholm, Sweden. (author)
  • Bejarano, David A.Univ Bonn, Life & Med Sci Inst LIMES, Quant Syst Biol, D-53115 Bonn, Germany. (author)
  • Flores, Ricardo O. RamirezHeidelberg Univ, Inst Computat Biomed, Heidelberg, Germany. (author)
  • Sorini, ChiaraKarolinska Institutet (author)
  • Larsson, LudvigKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u13lw4hm (author)
  • Luo, XinxinKarolinska Inst, Dept Med Solna, Div Immunol & Allergy, Stockholm, Sweden.;Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Ctr Mol Med, Stockholm, Sweden. (author)
  • Geerlings, LauraKarolinska Inst, Dept Med Solna, Div Immunol & Allergy, Stockholm, Sweden.;Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Ctr Mol Med, Stockholm, Sweden. (author)
  • Novella-Rausell, ClaudioKarolinska Inst, Dept Med Solna, Div Immunol & Allergy, Stockholm, Sweden.;Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Ctr Mol Med, Stockholm, Sweden. (author)
  • Zagami, ChiaraKarolinska Inst, Dept Med Solna, Div Immunol & Allergy, Stockholm, Sweden.;Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Ctr Mol Med, Stockholm, Sweden. (author)
  • Kuiper, RaoulKarolinska Institutet (author)
  • Morales, Rodrigo A.Karolinska Inst, Dept Med Solna, Div Immunol & Allergy, Stockholm, Sweden.;Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Ctr Mol Med, Stockholm, Sweden. (author)
  • Castillo, FranciscaKarolinska Inst, Dept Med Solna, Div Immunol & Allergy, Stockholm, Sweden.;Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Ctr Mol Med, Stockholm, Sweden. (author)
  • Hunt, MatthewUniv Hosp, Stockholm, Sweden.;Karolinska Inst, Ctr Mol Med, Stockholm, Sweden.;Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden. (author)
  • Mariano, Livia LacerdaInst Curie, Inserm U932 Immun & Canc, 12 Rue Lhomond, Paris, France. (author)
  • Hu, Yue O. O.Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Ctr Translat Microbiome Res, Stockholm, Sweden. (author)
  • Engblom, CamillaKarolinska Institutet (author)
  • Lennon-Dumenil, Ana-MariaInst Curie, Inserm U932 Immun & Canc, 12 Rue Lhomond, Paris, France. (author)
  • Mittenzwei, RomyJohannes Gutenberg Univ Mainz, Univ Med Ctr Mainz, Inst Mol Med, D-55131 Mainz, Germany. (author)
  • Westendorf, Astrid M.Johannes Gutenberg Univ Mainz, Univ Med Ctr Mainz, Res Ctr Immunotherapy FZI, D-55131 Mainz, Germany. Univ Duisburg Essen, Univ Hosp Essen, Inst Med Microbiol, Essen, Germany. (author)
  • Hoevelmeyer, NadineJohannes Gutenberg Univ Mainz, Univ Med Ctr Mainz, Inst Mol Med, D-55131 Mainz, Germany. (author)
  • Lundeberg, JoakimKTH,Science for Life Laboratory, SciLifeLab,Genteknologi(Swepub:kth)u1qkn9kw (author)
  • Saez-Rodriguez, JulioHeidelberg Univ, Inst Computat Biomed, Heidelberg, Germany. (author)
  • Schlitzer, AndreasUniv Bonn, Life & Med Sci Inst LIMES, Quant Syst Biol, D-53115 Bonn, Germany. (author)
  • Das, SrustidharKarolinska Institutet (author)
  • Villablanca, Eduardo J.Karolinska Institutet (author)
  • Karolinska Inst, Dept Med Solna, Div Immunol & Allergy, Stockholm, Sweden.;Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Ctr Mol Med, Stockholm, Sweden.Karolinska Inst, Dept Med Solna, Div Immunol & Allergy, Stockholm, Sweden.;Univ Hosp, Stockholm, Sweden. (creator_code:org_t)

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  • In:Immunity: Elsevier BV55:12, s. 2336-+1074-76131097-4180

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