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Therapeutic hypothe...
Therapeutic hypothermia can be induced and maintained using either commercial water bottles or a "phase changing material'' mattress in a newborn piglet model
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Iwata, S. (author)
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Iwata, O. (author)
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- Olson, L. (author)
- Karolinska Institutet
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Kapetanakis, A. (author)
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Kato, T. (author)
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Evans, S. (author)
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Araki, Y. (author)
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Kakuma, T. (author)
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Matsuishi, T. (author)
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- Setterwall, Fredrik (author)
- KTH,Energiprocesser
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- Lagercrantz, H. (author)
- Karolinska Institutet
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Robertson, N. J. (author)
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(creator_code:org_t)
- 2009-03-12
- 2009
- English.
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In: Archives of Disease in Childhood. - : BMJ. - 0003-9888 .- 1468-2044. ; 94:5, s. 387-391
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- Background: Therapeutic hypothermia, a safe and effective treatment for neonatal encephalopathy in an intensive care setting, is not available in low-resource settings. Aims/Methods: To assess two low-tech, low-cost cooling devices for use in low-resource settings: (i) commercially available water bottles filled with tepid water (25 degrees C); (ii) a mattress made of phase changing material (PCM) with a melting point of 32 degrees C (PCM works as a heat buffer at this temperature). Eleven anaesthetised newborn piglets were studied following transient hypoxia-ischaemia. The cooling device was applied 2-26 h after hypoxia-ischaemia with a target rectal temperature (T-rectal) of 33-34 degrees C. T-rectal undershoot was adjusted using cotton blankets; the cooling device was renewed when T-rectal rose above 35 degrees C. T-rectal data during cooling were dichotomised (within or without target) to assess: (a) the total period within the target T-rectal range; (b) the stability and fluctuation of T-rectal during cooling. Results: Therapeutic hypothermia was achieved with both water bottles (n=5) and the PCM mattress (n=6). The mean (SD) time to reach target T-rectal was 1.8 (0.5) h with water bottles and 1.9 (0.3) h with PCM. PCM cooling led to a longer period within the target T-rectal range (p<0.01) and more stable cooling (p<0.05). Water bottle cooling required device renewal (in four out of five piglets). Conclusion: Simple, low-tech cooling devices can induce and maintain therapeutic hypothermia effectively in a porcine model of neonatal encephalopathy, although frequent fine tuning by adjusting the number of blankets insulating the piglet was required to maintain a stable temperature. PCM may induce more stable cooling compared with water bottles.
Keyword
- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Iwata, S.
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Iwata, O.
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Olson, L.
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Kapetanakis, A.
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Kato, T.
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Evans, S.
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show more...
-
Araki, Y.
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Kakuma, T.
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Matsuishi, T.
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Setterwall, Fred ...
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Lagercrantz, H.
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Robertson, N. J.
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show less...
- Articles in the publication
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Archives of Dise ...
- By the university
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Royal Institute of Technology
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Karolinska Institutet