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  • Hyun, Gyu HwanCollege of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea (author)

Multivalent Carbohydrate Nanocomposites for Tumor Microenvironment Remodeling to Enhance Antitumor Immunity

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • American Chemical Society (ACS),2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-328864
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-328864URI
  • https://doi.org/10.1021/acsnano.3c01645DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20230613
  • Current cancer immunotherapeutic strategies mainly focus on remodeling the tumor microenvironment (TME) to make it favorable for antitumor immunity. Increasing attention has been paid to developing innovative immunomodulatory adjuvants that can restore weakened antitumor immunity by conferring immunogenicity to inflamed tumor tissues. Here, a galactan-enriched nanocomposite (Gal-NC) is developed from native carbohydrate structures through an optimized enzymatic transformation for effective, stable, and biosafe innate immunomodulation. Gal-NC is characterized as a carbohydrate nanoadjuvant with a macrophage-targeting feature. It is composed of repeating galactan glycopatterns derived from heteropolysaccharide structures of plant origin. The galactan repeats of Gal-NC function as multivalent pattern-recognition sites for Toll-like receptor 4 (TLR4). Functionally, Gal-NC-mediated TLR activation induces the repolarization of tumor-associated macrophages (TAMs) toward immunostimulatory/tumoricidal M1-like phenotypes. Gal-NC increases the intratumoral population of cytotoxic T cells, the main effector cells of antitumor immunity, via re-educated TAMs. These TME alterations synergistically enhance the T-cell-mediated antitumor response induced by αPD-1 administration, suggesting that Gal-NC has potential value as an adjuvant for immune checkpoint blockade combination therapies. Thus, the Gal-NC model established herein suggests a glycoengineering strategy to design a carbohydrate-based nanocomposite for advanced cancer immunotherapies.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Jeong, Da-HyeDepartment of Biochemistry, Ajou University School of Medicine, Suwon 16499, Republic of Korea;Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Republic of Korea (author)
  • Yang, Yoon YoungCollege of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea (author)
  • Cho, In HoCollege of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea (author)
  • Ha, Yu-JinDepartment of Biochemistry, Ajou University School of Medicine, Suwon 16499, Republic of Korea;Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Republic of Korea (author)
  • Xing, XiaohuiLethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, Alberta T1J 4B1, Canada (author)
  • Abbott, D. WadeLethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, Alberta T1J 4B1, Canada (author)
  • Hsieh, Yves S. Y.KTH,Glykovetenskap,School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan(Swepub:kth)u1a596wi (author)
  • Kang, Yun PyoCollege of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea (author)
  • Cha, Jong-HoDepartment of Biomedical Science, College of Medicine, and Program in Biomedical Sciences and Engineering, Inha University, Incheon 22332, Republic of Korea (author)
  • Hong, Soon-SunDepartment of Biomedical Science, College of Medicine, and Program in Biomedical Sciences and Engineering, Inha University, Incheon 22332, Republic of Korea (author)
  • Lee, Seul JiCollege of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea;College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea (author)
  • Kim, You-SunDepartment of Biochemistry, Ajou University School of Medicine, Suwon 16499, Republic of Korea;Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Republic of Korea (author)
  • Kwon, Sung WonCollege of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea (author)
  • College of Pharmacy, Seoul National University, Seoul 08826, Republic of KoreaDepartment of Biochemistry, Ajou University School of Medicine, Suwon 16499, Republic of Korea;Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Republic of Korea (creator_code:org_t)

Related titles

  • In:ACS Nano: American Chemical Society (ACS)17:12, s. 11567-115821936-08511936-086X

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