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Clinical proteomics...
Clinical proteomics and molecular pathology
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- Liotta, Lance A. (author)
- Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, United States
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- Davis, Justin B. (author)
- Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, United States
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- Zhou, Weidong (author)
- Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, United States
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- Petricoin, Emanuel (author)
- Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, United States
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- Espina, Virginia (author)
- Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, United States
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- Couch, Robin D. (author)
- Department of Chemistry and Biochemistry, George Mason University, Manassas, VA, United States
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- Fredolini, Claudia (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: Essential Concepts in Molecular Pathology. - : Elsevier BV. ; , s. 149-163
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Genomic and proteomic research is launching the next era of cancer molecular medicine. Molecular expression profiles can uncover clues to functionally important molecules in the development of human disease and generate information to subclassify human tumors and tailor a treatment to the individual patient. The next revolution is the synthesis of proteomic information into functional pathways and circuits in cells and tissues. Such synthesis must take into account the dynamic state of protein post-translational modifications; protein-protein or protein-DNA/RNA interactions; cross-talk between signal pathways; and feedback regulation within cells, between cells, and between tissues. This full set of information may be required before we can fully dissect the specific dysregulated pathways driving tumorigenesis. This higher level of functional understanding will be the basis for true rational therapeutic design that specifically targets the molecular lesions underlying human disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- Analyte
- Antibody
- Biomarker
- Microdissection
- Proteomics
- Tumorigenesis
Publication and Content Type
- vet (subject category)
- kap (subject category)
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