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An integrated centr...
An integrated centrifugal microfluidic platform for multiplexed colorimetric immunodetection of protein biomarkers in resource-limited settings
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- Akhtar, Ahmad Saleem (author)
- KTH,Nanobioteknologi,Science for Life Laboratory, SciLifeLab
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- Pinto, Ines Fernandes (author)
- KTH,Nanobioteknologi,Science for Life Laboratory, SciLifeLab
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- Soares, Ruben R. G. (author)
- KTH,Science for Life Laboratory, SciLifeLab,Nanobioteknologi
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- Russom, Aman, Prof. 1976- (author)
- KTH,Science for Life Laboratory, SciLifeLab,Nanobioteknologi
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(creator_code:org_t)
- Chemical and Biological Microsystems Society, 2021
- 2021
- English.
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In: Proceedings MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. - : Chemical and Biological Microsystems Society. ; , s. 947-948
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- The up- and down- regulation of inflammatory biomarkers such as cytokines can be indicative of several diseases such as primary cancers and/or metastatic tumors, as well as less serious conditions. For point-of-care clinical applications, the detection of these biomarkers requires a combination of a sensitive assay and multiplexing capabilities, together with fit-for-purpose signal transduction strategies. Here, we report the development of a versatile and cost-effective integrated centrifugal microfluidic platform compatible with resource-limited settings using nanoporous microbeads for immunoaffinity-based profiling of cytokines. With an automated colorimetric readout at the end, the platform allows for profiling of cytokines in < 30 mins.
Subject headings
- NATURVETENSKAP -- Kemi -- Annan kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Other Chemistry Topics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Centrifugal microfluidics
- Colorimetry
- Cytokines
- Point-of-Care
Publication and Content Type
- ref (subject category)
- kon (subject category)
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