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Injectable 2D flexi...
Injectable 2D flexible hydrogel sheets for optoelectrical/biochemical dual stimulation of neurons
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- Amagat, Jordi (author)
- Department of Biological and Chemical Engineering, Aarhus University, Denmark; Sino-Danish College (SDC), University of Chinese Academy of Sciences, Beijing 101400, China
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- Müller, Christoph Alexander (author)
- Department of Biological and Chemical Engineering, Aarhus University, Denmark
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- Jensen, Bjarke Nørrehvedde (author)
- Department of Biological and Chemical Engineering, Aarhus University, Denmark
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- Xiong, Xuya (author)
- Interdisciplinary Nanoscience Center, iNANO, Aarhus University, Denmark
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- Su, Yingchun (author)
- KTH,Elektronik och inbyggda system,Department of Biological and Chemical Engineering, Aarhus University, Denmark
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- Christensen, Natasja Porskjær (author)
- Department of Biological and Chemical Engineering, Aarhus University, Denmark
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- Le Friec, Alice (author)
- Department of Biological and Chemical Engineering, Aarhus University, Denmark
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- Dong, Mingdong (author)
- Interdisciplinary Nanoscience Center, iNANO, Aarhus University, Denmark
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- Fang, Ying (author)
- CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, People's Republic of China; CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, People's Republic of China
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- Chen, Menglin (author)
- Department of Biological and Chemical Engineering, Aarhus University, Denmark; Interdisciplinary Nanoscience Center, iNANO, Aarhus University, Denmark
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
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In: Biomaterials Advances. - : Elsevier BV. - 2772-9516 .- 2772-9508. ; 146
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Major challenges in developing implanted neural stimulation devices are the invasiveness, complexity, and cost of the implantation procedure. Here, we report an injectable, nanofibrous 2D flexible hydrogel sheet-based neural stimulation device that can be non-invasively implanted via syringe injection for optoelectrical and biochemical dual stimulation of neuron. Specifically, methacrylated gelatin (GelMA)/alginate hydrogel nanofibers were mechanically reinforced with a poly(lactide-co-ε-caprolactone) (PLCL) core by coaxial electrospinning. The lubricant hydrogel shell enabled not only injectability, but also facile incorporation of functional nanomaterials and bioactives. The nanofibers loaded with photocatatlytic g-C3N4/GO nanoparticles were capable of stimulating neural cells via blue light, with a significant 36.3 % enhancement in neurite extension. Meanwhile, the nerve growth factor (NGF) loaded nanofibers supported a sustained release of NGF with well-maintained function to biochemically stimulate neural differentiation. We have demonstrated the capability of an injectable, hydrogel nanofibrous, neural stimulation system to support neural stimulation both optoelectrically and biochemically, which represents crucial early steps in a larger effort to create a minimally invasive system for neural stimulation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Keyword
- Core-shell fibers
- Electrospinning
- Growth factor release
- Neural regeneration
- Optoelectrical stimulation
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Amagat, Jordi
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Müller, Christop ...
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Jensen, Bjarke N ...
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Xiong, Xuya
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Su, Yingchun
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Christensen, Nat ...
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show more...
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Le Friec, Alice
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Dong, Mingdong
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Fang, Ying
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Chen, Menglin
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomaterials Sci ...
- Articles in the publication
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Biomaterials Adv ...
- By the university
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Royal Institute of Technology