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The acute effect of...
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Li, XiangyuKTH,Systembiologi,Science for Life Laboratory, SciLifeLab,Bash Biotech Inc, 600 West Broadway, Suite 700, San Diego, CA 92101, USA, 600 West Broadway, Suite 700; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden; Guangzhou Laboratory, Guangzhou 510005, China,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
(author)
The acute effect of different NAD+ precursors included in the combined metabolic activators
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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Elsevier BV,2023
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-331449
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-331449URI
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https://doi.org/10.1016/j.freeradbiomed.2023.05.032DOI
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https://research.chalmers.se/publication/536222URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20230707
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NAD+ and glutathione precursors are currently used as metabolic modulators for improving the metabolic conditions associated with various human diseases, including non-alcoholic fatty liver disease, neurodegenerative diseases, mitochondrial myopathy, and age-induced diabetes. Here, we performed a one-day double blinded, placebo-controlled human clinical study to assess the safety and acute effects of six different Combined Metabolic Activators (CMAs) with 1 g of different NAD+ precursors based on global metabolomics analysis. Our integrative analysis showed that the NAD+ salvage pathway is the main source for boosting the NAD+ levels with the administration of CMAs without NAD+ precursors. We observed that incorporation of nicotinamide (Nam) in the CMAs can boost the NAD+ products, followed by niacin (NA), nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), but not flush free niacin (FFN). In addition, the NA administration led to a flushing reaction, accompanied by decreased phospholipids and increased bilirubin and bilirubin derivatives, which could be potentially risky. In conclusion, this study provided a plasma metabolomic landscape of different CMA formulations, and proposed that CMAs with Nam, NMN as well as NR can be administered for boosting NAD+ levels to improve altered metabolic conditions.
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Yang, HongKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:kth)u150v7zg
(author)
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Jin, HanKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH),Göteborgs universitet,University of Gothenburg(Swepub:kth)u19wdovm
(author)
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Turkez, HasanDepartment of Medical Biology, Faculty of Medicine, Ataturk University, Erzurum, Turkey,Atatürk Üniversitesi,Atatürk University
(author)
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Ozturk, GurkanResearch Institute for Health Sciences and Technologies (SABITA), International School of Medicine, Istanbul Medipol University, 34810 Istanbul, Turkey,Istanbul Medipol Universitesi
(author)
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Doganay, Hamdi LeventGastroenterology and Hepatology Unit, VM Pendik Medicalpark Teaching Hospital, Istanbul, Turkey; Department of Internal Medicine, Bahcesehir University (BAU), Istanbul, Turkey
(author)
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Zhang, ChengKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:cth)chengz
(author)
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Nielsen, Jens B,1962Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden; BioInnovation Institute, Ole Maaloees Vej 3, DK2200, Copenhagen, Denmark, Ole Maaløes Vej 3,BioInnovation Institute (BII),Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj
(author)
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Uhlén, MathiasKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:kth)u1dulvmw
(author)
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Borén, JanDepartment of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden
(author)
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Mardinoglu, AdilKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, United Kingdom,King's College London,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:cth)adilm
(author)
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KTHSystembiologi
(creator_code:org_t)
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In:Free Radical Biology & Medicine: Elsevier BV205, s. 77-890891-58491873-4596
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Li, Xiangyu
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Yang, Hong
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Jin, Han
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Turkez, Hasan
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Ozturk, Gurkan
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Zhang, Cheng
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Uhlén, Mathias
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