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  • Li, XiangyuKTH,Systembiologi,Science for Life Laboratory, SciLifeLab,Bash Biotech Inc, 600 West Broadway, Suite 700, San Diego, CA 92101, USA, 600 West Broadway, Suite 700; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden; Guangzhou Laboratory, Guangzhou 510005, China,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH) (author)

The acute effect of different NAD+ precursors included in the combined metabolic activators

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Elsevier BV,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-331449
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-331449URI
  • https://doi.org/10.1016/j.freeradbiomed.2023.05.032DOI
  • https://research.chalmers.se/publication/536222URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20230707
  • NAD+ and glutathione precursors are currently used as metabolic modulators for improving the metabolic conditions associated with various human diseases, including non-alcoholic fatty liver disease, neurodegenerative diseases, mitochondrial myopathy, and age-induced diabetes. Here, we performed a one-day double blinded, placebo-controlled human clinical study to assess the safety and acute effects of six different Combined Metabolic Activators (CMAs) with 1 g of different NAD+ precursors based on global metabolomics analysis. Our integrative analysis showed that the NAD+ salvage pathway is the main source for boosting the NAD+ levels with the administration of CMAs without NAD+ precursors. We observed that incorporation of nicotinamide (Nam) in the CMAs can boost the NAD+ products, followed by niacin (NA), nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), but not flush free niacin (FFN). In addition, the NA administration led to a flushing reaction, accompanied by decreased phospholipids and increased bilirubin and bilirubin derivatives, which could be potentially risky. In conclusion, this study provided a plasma metabolomic landscape of different CMA formulations, and proposed that CMAs with Nam, NMN as well as NR can be administered for boosting NAD+ levels to improve altered metabolic conditions.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Yang, HongKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:kth)u150v7zg (author)
  • Jin, HanKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH),Göteborgs universitet,University of Gothenburg(Swepub:kth)u19wdovm (author)
  • Turkez, HasanDepartment of Medical Biology, Faculty of Medicine, Ataturk University, Erzurum, Turkey,Atatürk Üniversitesi,Atatürk University (author)
  • Ozturk, GurkanResearch Institute for Health Sciences and Technologies (SABITA), International School of Medicine, Istanbul Medipol University, 34810 Istanbul, Turkey,Istanbul Medipol Universitesi (author)
  • Doganay, Hamdi LeventGastroenterology and Hepatology Unit, VM Pendik Medicalpark Teaching Hospital, Istanbul, Turkey; Department of Internal Medicine, Bahcesehir University (BAU), Istanbul, Turkey (author)
  • Zhang, ChengKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:cth)chengz (author)
  • Nielsen, Jens B,1962Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden; BioInnovation Institute, Ole Maaloees Vej 3, DK2200, Copenhagen, Denmark, Ole Maaløes Vej 3,BioInnovation Institute (BII),Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj (author)
  • Uhlén, MathiasKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:kth)u1dulvmw (author)
  • Borén, JanDepartment of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden (author)
  • Mardinoglu, AdilKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, United Kingdom,King's College London,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:cth)adilm (author)
  • KTHSystembiologi (creator_code:org_t)

Related titles

  • In:Free Radical Biology & Medicine: Elsevier BV205, s. 77-890891-58491873-4596

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