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Elevated plasma com...
Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism
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- Iglesias, Maria Jesus (author)
- KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Division of Internal Medicine, University Hospital of North Norway (UNN), PB100, 9038, Tromsø, Norway; Translational Vascular Research, Department of Clinical Medicine, UiT The Arctic University of Norway, 9019, Tromsø, Norway
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- Sanchez-Rivera, Laura (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Ibrahim-Kosta, Manal (author)
- Aix-Marseille Univ, INSERM, INRAE, C2VN, Laboratory of Haematology, CRB Assistance Publique—Hôpitaux de Marseille, HemoVasc (CRB AP-HM HemoVasc), Marseille, France, HemoVasc (CRB AP-HM HemoVasc)
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- Naudin, Clément (author)
- KTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,Translational Vascular Research, Department of Clinical Medicine, UiT The Arctic University of Norway, 9019, Tromsø, Norway
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- Munsch, Gaëlle (author)
- University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, ELEANOR, Bordeaux, France, ELEANOR
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- Goumidi, Louisa (author)
- Aix-Marseille Univ, INSERM, INRAE, C2VN, Laboratory of Haematology, CRB Assistance Publique—Hôpitaux de Marseille, HemoVasc (CRB AP-HM HemoVasc), Marseille, France, HemoVasc (CRB AP-HM HemoVasc)
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- Farm, Maria (author)
- Karolinska Institutet
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- Smith, Philip M. (author)
- Karolinska Institutet
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- Thibord, Florian (author)
- Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, MA, USA; The Framingham Heart Study, Boston University, Framingham, MA, USA
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- Kral-Pointner, Julia Barbara (author)
- Center for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
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- Hong, Mun-Gwan (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap
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- Suchon, Pierre (author)
- Aix-Marseille Univ, INSERM, INRAE, C2VN, Laboratory of Haematology, CRB Assistance Publique—Hôpitaux de Marseille, HemoVasc (CRB AP-HM HemoVasc), Marseille, France, HemoVasc (CRB AP-HM HemoVasc)
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- Germain, Marine (author)
- University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, ELEANOR, Bordeaux, France, ELEANOR; Laboratory of Excellence GENMED (Medical Genomics), Bordeaux, France
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- Schottmaier, Waltraud (author)
- Center for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
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- Dusart, Philip (author)
- KTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,Translational Vascular Research, Department of Clinical Medicine, UiT The Arctic University of Norway, 9019, Tromsø, Norway
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- Boland, Anne (author)
- Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France; Laboratory of Excellence GENMED (Medical Genomics), Evry, France
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- Kotol, David (author)
- KTH,Systembiologi,Science for Life Laboratory, SciLifeLab
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- Edfors, Fredrik (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi
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- Koprulu, Mine (author)
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK
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- Pietzner, Maik (author)
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK; Computational Medicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK
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- Langenberg, Claudia (author)
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK; Computational Medicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK
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- Damrauer, Scott M. (author)
- Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA; Department of Surgery and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
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- Johnson, Andrew D. (author)
- Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, MA, USA; The Framingham Heart Study, Boston University, Framingham, MA, USA
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- Klarin, Derek M. (author)
- VA Palo Alto Healthcare System, Palo Alto, CA, USA; Department of Vascular Surgery, Stanford University School of Medicine, Palo Alto, CA, USA
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- Smith, Nicholas L. (author)
- Department of Epidemiology, University of Washington, Seattle, WA, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA, USA
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- Smadja, David M. (author)
- Hematology Department and Biosurgical Research Lab (Carpentier Foundation), European Georges Pompidou Hospital, Assistance Publique Hôpitaux de Paris, 20 rue Leblanc, Paris, 75015, France, 20 rue Leblanc; Innovative Therapies in Haemostasis, INSERM, Université de Paris, 4 avenue de l’Observatoire, Paris, 75270, France, 4 avenue de l’Observatoire
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- Holmström, Margareta (author)
- Coagulation Unit, Department of Haematology, Karolinska University Hospital, SE-171 76, Stockholm, Sweden, SE-171 76
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- Magnusson, Maria (author)
- Karolinska Institutet
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- Silveira, Angela (author)
- Karolinska Institutet
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- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi
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- Renné, Thomas (author)
- Institute for Clinical Chemistry and Laboratory Medicine, University Medical Centre Hamburg-Eppendorf, D-20246, Hamburg, Germany; Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, D-, 55131, Mainz, Germany; Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin 2, D02 YN77, Ireland
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- Martinez-Perez, Angel (author)
- Genomics of Complex Diseases Group, Research Institute Hospital de la Santa Creu i Sant Pau. IIB Sant Pau, Barcelona, Spain
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- Emmerich, Joseph (author)
- Department of vascular medicine, Paris Saint-Joseph Hospital Group, INSERM 1153-CRESS, University of Paris Cité, 185 rue Raymond Losserand, Paris, 75674, France, 185 rue Raymond Losserand
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- Deleuze, Jean Francois (author)
- Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine (CNRGH), 91057, Evry, France; Laboratory of Excellence GENMED (Medical Genomics), Evry, France; Centre D’Etude du Polymorphisme Humain, Fondation Jean Dausset, Paris, France
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- Antovic, Jovan (author)
- Karolinska Institutet
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- Soria Fernandez, Jose Manuel (author)
- Genomics of Complex Diseases Group, Research Institute Hospital de la Santa Creu i Sant Pau. IIB Sant Pau, Barcelona, Spain
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- Assinger, Alice (author)
- Center for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
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- Schwenk, Jochen M. (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Souto Andres, Joan Carles (author)
- Unitat d’Hemostàsia i Trombosi. Hospital de la Santa Creu i Sant Pau and IIB-Sant Pau, Barcelona, Spain
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- Morange, Pierre Emmanuel (author)
- Aix-Marseille Univ, INSERM, INRAE, C2VN, Laboratory of Haematology, CRB Assistance Publique—Hôpitaux de Marseille, HemoVasc (CRB AP-HM HemoVasc), Marseille, France, HemoVasc (CRB AP-HM HemoVasc)
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- Butler, Lynn M. (author)
- KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Translational Vascular Research, Department of Clinical Medicine, UiT The Arctic University of Norway, 9019, Tromsø, Norway; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden; Department of Clinical Chemistry, Karolinska University Hospital, Stockholm, Sweden
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- Trégouët, David Alexandre (author)
- University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, ELEANOR, Bordeaux, France, ELEANOR; Laboratory of Excellence GENMED (Medical Genomics), Bordeaux, France
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- Odeberg, Jacob, Professor, 1963- (author)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Division of Internal Medicine, University Hospital of North Norway (UNN), PB100, 9038, Tromsø, Norway; Translational Vascular Research, Department of Clinical Medicine, UiT The Arctic University of Norway, 9019, Tromsø, Norway; Department of Medicine Solna, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden; Coagulation Unit, Department of Haematology, Karolinska University Hospital, SE-171 76, Stockholm, Sweden, SE-171 76
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(creator_code:org_t)
- Springer Nature, 2023
- 2023
- English.
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious short- and long-term complications. In clinical practice, there is a need for improved plasma biomarker-based tools for VTE diagnosis and risk prediction. Here we show, using proteomics profiling to screen plasma from patients with suspected acute VTE, and several case-control studies for VTE, how Complement Factor H Related 5 protein (CFHR5), a regulator of the alternative pathway of complement activation, is a VTE-associated plasma biomarker. In plasma, higher CFHR5 levels are associated with increased thrombin generation potential and recombinant CFHR5 enhanced platelet activation in vitro. GWAS analysis of ~52,000 participants identifies six loci associated with CFHR5 plasma levels, but Mendelian randomization do not demonstrate causality between CFHR5 and VTE. Our results indicate an important role for the regulation of the alternative pathway of complement activation in VTE and that CFHR5 represents a potential diagnostic and/or risk predictive plasma biomarker.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Iglesias, Maria ...
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Sanchez-Rivera, ...
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Ibrahim-Kosta, M ...
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Naudin, Clément
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Munsch, Gaëlle
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Goumidi, Louisa
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show more...
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Farm, Maria
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Smith, Philip M.
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Thibord, Florian
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Kral-Pointner, J ...
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Hong, Mun-Gwan
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Suchon, Pierre
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Germain, Marine
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Schottmaier, Wal ...
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Dusart, Philip
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Boland, Anne
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Kotol, David
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Edfors, Fredrik
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Koprulu, Mine
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Pietzner, Maik
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Langenberg, Clau ...
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Damrauer, Scott ...
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Johnson, Andrew ...
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Klarin, Derek M.
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Smith, Nicholas ...
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Smadja, David M.
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Holmström, Marga ...
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Magnusson, Maria
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Silveira, Angela
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Uhlén, Mathias
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Renné, Thomas
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Martinez-Perez, ...
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Emmerich, Joseph
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Deleuze, Jean Fr ...
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Antovic, Jovan
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Soria Fernandez, ...
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Assinger, Alice
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Schwenk, Jochen ...
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Souto Andres, Jo ...
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Morange, Pierre ...
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Butler, Lynn M.
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Trégouët, David ...
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Odeberg, Jacob, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
- Articles in the publication
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Nature Communica ...
- By the university
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Royal Institute of Technology
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Karolinska Institutet