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Triazole fungicides...
Triazole fungicides induce adipogenesis and repress osteoblastogenesis in zebrafish
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- Thrikawala, Savini (author)
- Department of Biological Sciences, Clemson University, Clemson, South Carolina, USA
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- Mesmar, Fahmi (author)
- Department of Intelligent Systems Engineering, Indiana University, Bloomington, Indiana, USA
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- Bhattacharya, Beas (author)
- Department of Intelligent Systems Engineering, Indiana University, Bloomington, Indiana, USA
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- Muhsen, Maram (author)
- Department of Intelligent Systems Engineering, Indiana University, Bloomington, Indiana, USA
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- Mukhopadhyay, Srijita (author)
- Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA
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- Flores, Sara (author)
- Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, USA
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- Upadhyay, Sanat (author)
- Lolaark Vision Inc, Houston, Texas, USA
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- Vergara, Leoncio (author)
- Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, USA
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- Gustafsson, Jan Åke (author)
- Karolinska Institutet
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- Williams, Cecilia, Professor, 1969- (author)
- KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik
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- Bondesson, Maria (author)
- Department of Intelligent Systems Engineering, Indiana University, Bloomington, Indiana, USA
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(creator_code:org_t)
- 2023-03-23
- 2023
- English.
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In: Toxicological Sciences. - : Oxford University Press (OUP). - 1096-6080 .- 1096-0929. ; 193:2, s. 119-130
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Triazoles are a major group of azole fungicides commonly used in agriculture, and veterinary and human medicine. Maternal exposure to certain triazole antifungal medication causes congenital malformations, including skeletal malformations. We hypothesized that triazoles used as pesticides in agriculture also pose a risk of causing skeletal malformations in developing embryos. In this study, teratogenic effects of three commonly used triazoles, cyproconazole, paclobutrazol, and triadimenol, were investigated in zebrafish, Danio rerio. Exposure to the triazole fungicides caused bone and cartilage malformations in developing zebrafish larvae. Data from whole-embryo transcriptomics with cyproconazole suggested that exposure to this compound induces adipogenesis while repressing skeletal development. Confirming this finding, the expression of selected bone and cartilage marker genes were significantly downregulated with triazoles exposure as determined by quantitative PCR. The expression of selected adipogenic genes was upregulated by the triazoles. Furthermore, exposure to each of the three triazoles induced adipogenesis and lipid droplet formation in vitro in 3T3-L1 pre-adipocyte cells. In vivo in zebrafish larvae, cyproconazole exposure caused lipid accumulation. These results suggest that exposure to triazoles promotes adipogenesis at the expense of skeletal development, and thus they expand the chemical group of bona fide bone to fat switchers.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- adipocytes
- adverse effects
- embryo malformations
- skeleton
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Thrikawala, Savi ...
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Mesmar, Fahmi
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Bhattacharya, Be ...
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Muhsen, Maram
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Mukhopadhyay, Sr ...
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Flores, Sara
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show more...
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Upadhyay, Sanat
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Vergara, Leoncio
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Gustafsson, Jan ...
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Williams, Cecili ...
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Bondesson, Maria
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Toxicological Sc ...
- By the university
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Royal Institute of Technology
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Karolinska Institutet