Search: onr:"swepub:oai:DiVA.org:kth-33526" >
Repair of DNA Dewar...
-
Ai, Yue-Jie,1982-KTH,Teoretisk kemi och biologi
(author)
Repair of DNA Dewar Photoproduct to (6-4) photoproduct in (6-4) Photolyase
- Article/chapterEnglish2011
Publisher, publication year, extent ...
-
2011-08-29
-
American Chemical Society (ACS),2011
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:kth-33526
-
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-33526URI
-
https://doi.org/10.1021/jp204128kDOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-66532URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
QC 20111010
-
authorCount :6
-
Dewar photoproduct (Dewar PP) is the valence isomer of (6-4) photoproduct ((6-4)PP) in photodamaged DNA. Compared to the extensive studied CPD photoproducts, the underlying repair mechanisms for the (6-4)PP, and especially for the Dewar PP, are not well-established to date. In this paper, the repair mechanism of DNA Dewar photoproduct T(dew)C in (6-4) photolyase was elucidated using hybrid density functional theory. Our results showed that, during the repair process, the T(dew)C has to isomerize to T(6-4)C photolesion first via direct C6'-N3' bond cleavage facilitated by electron injection. This isomerization mechanism is energetically much more efficient than other possible rearrangement pathways. The calculations provide a theoretical interpretation to recent experimental observations.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Liao, Rongzhen,1983-Stockholm University
(author)
-
Chen, ShiluBeijing Institute of Technology
(author)
-
Hua, Wei-JieKTH,Teoretisk kemi och biologi(Swepub:kth)u16a94ty
(author)
-
Fang, Wei-Hai
(author)
-
Luo, YiKTH,Teoretisk kemi och biologi(Swepub:kth)u126eitw
(author)
-
Liao, Rong-ZhenStockholms universitet,Institutionen för organisk kemi
(author)
-
Chen, Shi-Lu
(author)
-
KTHTeoretisk kemi och biologi
(creator_code:org_t)
Related titles
-
In:Journal of Physical Chemistry B: American Chemical Society (ACS)115:37, s. 10976-109821520-61061520-5207
Internet link
Find in a library
To the university's database
- By the author/editor
-
Ai, Yue-Jie, 198 ...
-
Liao, Rongzhen, ...
-
Chen, Shilu
-
Hua, Wei-Jie
-
Fang, Wei-Hai
-
Luo, Yi
-
show more...
-
Liao, Rong-Zhen
-
Chen, Shi-Lu
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Chemical Science ...
- Articles in the publication
-
Journal of Physi ...
- By the university
-
Royal Institute of Technology
-
Stockholm University