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Spatial transcriptomics of human placentas reveal distinct RNA patterns associated with morphology and preeclampsia
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- Bhalla, Nayanika (author)
- KTH Royal Institute of Technology,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Franzén, Lovisa (author)
- KTH Royal Institute of Technology,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Scheynius, Annika (author)
- Karolinska Institute
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- (creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
- In: Placenta. - : Elsevier BV. - 0143-4004 .- 1532-3102. ; 139, s. 213-216
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Spatial transcriptomics (ST) maps RNA level patterns within a tissue. This technology has not been previously applied to human placental tissue. We demonstrate analysis of human placental samples with ST. Unsupervised clustering revealed that distinct RNA patterns were found corresponding to different morphological structures. Additionally, when focusing upon terminal villi and hemoglobin associated structures, RNA levels differed between placentas from full term healthy pregnancies and those complicated by preeclampsia. The results from this study can provide a benchmark for future ST studies in placenta.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Differential gene expression
- Hemoglobin
- Morphology
- Oxidoreductase pathway
- Placenta
- Preeclampsia
- Pregnancy complications
- Spatial transcriptomics
- Villi
- Differential gene expression
- Hemoglobin
- Morphology
- Oxidoreductase pathway
- Placenta
- Preeclampsia
- Pregnancy complications
- Spatial transcriptomics
- Villi
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- art (subject category)
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- MEDICAL AND HEALTH SCIENCES
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- Articles in the publication
- Placenta
- By the university
- Royal Institute of Technology
- Lund University
- Karolinska Institutet
- Uppsala University
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