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- Bhalla, NayanikaKTH Royal Institute of Technology,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab (author)
Spatial transcriptomics of human placentas reveal distinct RNA patterns associated with morphology and preeclampsia
- Article/chapterEnglish2023
Publisher, publication year, extent ...
- Elsevier BV,2023
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:kth-335727
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-335727URI
- https://doi.org/10.1016/j.placenta.2023.07.004DOI
- https://lup.lub.lu.se/record/0ec1f633-97ad-464e-9ec3-fd77d60fd851URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:153450499URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-508744URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- QC 20230911
- Susanne Lager and Patrik L. Ståhl are shared senior authors.
- Spatial transcriptomics (ST) maps RNA level patterns within a tissue. This technology has not been previously applied to human placental tissue. We demonstrate analysis of human placental samples with ST. Unsupervised clustering revealed that distinct RNA patterns were found corresponding to different morphological structures. Additionally, when focusing upon terminal villi and hemoglobin associated structures, RNA levels differed between placentas from full term healthy pregnancies and those complicated by preeclampsia. The results from this study can provide a benchmark for future ST studies in placenta.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
- Differential gene expression
- Hemoglobin
- Morphology
- Oxidoreductase pathway
- Placenta
- Preeclampsia
- Pregnancy complications
- Spatial transcriptomics
- Villi
- Differential gene expression
- Hemoglobin
- Morphology
- Oxidoreductase pathway
- Placenta
- Preeclampsia
- Pregnancy complications
- Spatial transcriptomics
- Villi
Added entries (persons, corporate bodies, meetings, titles ...)
- Franzén, LovisaKTH Royal Institute of Technology,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1uxl018 (author)
- Scheynius, AnnikaKarolinska Institute (author)
- Papadogiannakis, NikosKarolinska Institute,Karolinska University Hospital (author)
- Hansson, Stefan R.Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för translationell obstetrisk forskning,Forskargrupper vid Lunds universitet,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Unit for translational obstetric research,Lund University Research Groups(Swepub:lu)gyn-sha (author)
- Lager, SusanneUppsala universitet,Uppsala University,Obstetrisk och reproduktiv hälsoforskning(Swepub:uu)susla462 (author)
- Ståhl, Patrik,Dr.KTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab,Genteknologi(Swepub:kth)u1rstx38 (author)
- KTHGenteknologi (creator_code:org_t)
Related titles
- In:Placenta: Elsevier BV139, s. 213-2160143-40041532-3102
Internet link
- https://doi.org/10.1016/j.placenta.2023.07.004Fulltext
- http://dx.doi.org/10.1016/j.placenta.2023.07.004FULLTEXT
- https://uu.diva-portal.org/smash/get/diva2:1786281/FULLTEXT01.pdffulltext:print
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-335727
- https://doi.org/10.1016/j.placenta.2023.07.004
- https://lup.lub.lu.se/record/0ec1f633-97ad-464e-9ec3-fd77d60fd851
- http://kipublications.ki.se/Default.aspx?queryparsed=id:153450499
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-508744
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