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  • Brilhante, Raimunda Sâmia NogueiraDepartment of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Postgraduate Program in Medical Sciences, Federal University of Ceará, Rua Barão de Canindé, 210, Montese, CE, Fortaleza, 60425-540, Brazil, Rua Barão de Canindé, 210, Montese, CE (author)

Antifungal Activity of Chitosan against Histoplasma capsulatum in Planktonic and Biofilm Forms : A Therapeutic Strategy in the Future?

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • MDPI AG,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-342147
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-342147URI
  • https://doi.org/10.3390/jof9121201DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20240115
  • Histoplasmosis is a respiratory disease caused by Histoplasma capsulatum, a dimorphic fungus, with high mortality and morbidity rates, especially in immunocompromised patients. Considering the small existing therapeutic arsenal, new treatment approaches are still required. Chitosan, a linear polysaccharide obtained from partial chitin deacetylation, has anti-inflammatory, antimicrobial, biocompatibility, biodegradability, and non-toxicity properties. Chitosan with different deacetylation degrees and molecular weights has been explored as a potential agent against fungal pathogens. In this study, the chitosan antifungal activity against H. capsulatum was evaluated using the broth microdilution assay, obtaining minimum inhibitory concentrations (MIC) ranging from 32 to 128 µg/mL in the filamentous phase and 8 to 64 µg/mL in the yeast phase. Chitosan combined with classical antifungal drugs showed a synergic effect, reducing chitosan’s MICs by 32 times, demonstrating that there were no antagonistic interactions relating to any of the strains tested. A synergism between chitosan and amphotericin B or itraconazole was detected in the yeast-like form for all strains tested. For H. capsulatum biofilms, chitosan reduced biomass and metabolic activity by about 40% at 512 µg/mL. In conclusion, studying chitosan as a therapeutic strategy against Histoplasma capsulatum is promising, mainly considering its numerous possible applications, including its combination with other compounds.

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  • Costa, Anderson da CunhaDepartment of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Postgraduate Program in Medical Sciences, Federal University of Ceará, Rua Barão de Canindé, 210, Montese, CE, Fortaleza, 60425-540, Brazil, Rua Barão de Canindé, 210, Montese, CE (author)
  • Mesquita, Jacó Ricarte Lima deSão José Hospital, Fortaleza, CE, 60455-610, Brazil, CE (author)
  • dos Santos Araújo, GessicaPostgraduate in Veterinary Sciences, Faculty of Veterinary, State University of Ceará, Dr. Silas Munguba Avenue, 1700, Itaperi Campus, CE, Fortaleza, 60714-903, Brazil, Dr. Silas Munguba Avenue, 1700, Itaperi Campus, CE (author)
  • Freire, Rosemeyre SouzaAnalytical Center, Department of Physics, Federal University of Ceará, Fortaleza, CE, 60020-181, Brazil, CE (author)
  • Nunes, João Victor SerraAnalytical Center, Department of Physics, Federal University of Ceará, Fortaleza, CE, 60020-181, Brazil, CE (author)
  • Nobre, Augusto Feynman DiasDepartment of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Postgraduate Program in Medical Sciences, Federal University of Ceará, Rua Barão de Canindé, 210, Montese, CE, Fortaleza, 60425-540, Brazil, Rua Barão de Canindé, 210, Montese, CE (author)
  • Fernandes, Mirele RodriguesDepartment of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Postgraduate Program in Medical Sciences, Federal University of Ceará, Rua Barão de Canindé, 210, Montese, CE, Fortaleza, 60425-540, Brazil, Rua Barão de Canindé, 210, Montese, CE (author)
  • Rocha, Marcos Fábio GadelhaPostgraduate in Veterinary Sciences, Faculty of Veterinary, State University of Ceará, Dr. Silas Munguba Avenue, 1700, Itaperi Campus, CE, Fortaleza, 60714-903, Brazil, Dr. Silas Munguba Avenue, 1700, Itaperi Campus, CE (author)
  • Pereira Neto, Waldemiro de AquinoDepartment of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Postgraduate Program in Medical Sciences, Federal University of Ceará, Rua Barão de Canindé, 210, Montese, CE, Fortaleza, 60425-540, Brazil, Rua Barão de Canindé, 210, Montese, CE (author)
  • Crouzier, ThomasKTH,Glykovetenskap(Swepub:kth)u1hi6ps2 (author)
  • Schimpf, UlrikeKTH,Glykovetenskap(Swepub:kth)u1kgv41z (author)
  • Viera, Rodrigo SilveiraDepartment of Chemical Engineering, Federal University of Ceará, CE, Fortaleza, 60440-900, Brazil, CE (author)
  • Department of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Postgraduate Program in Medical Sciences, Federal University of Ceará, Rua Barão de Canindé, 210, Montese, CE, Fortaleza, 60425-540, Brazil, Rua Barão de Canindé, 210, Montese, CESão José Hospital, Fortaleza, CE, 60455-610, Brazil, CE (creator_code:org_t)

Related titles

  • In:Journal of Fungi: MDPI AG9:122309-608X

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