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Search: onr:"swepub:oai:DiVA.org:kth-344172" > Clonally heritable ...

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  • Mold, Jeff E.Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden (author)

Clonally heritable gene expression imparts a layer of diversity within cell types

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • Elsevier BV,2024
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-344172
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-344172URI
  • https://doi.org/10.1016/j.cels.2024.01.004DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20240308
  • Cell types can be classified according to shared patterns of transcription. Non-genetic variability among individual cells of the same type has been ascribed to stochastic transcriptional bursting and transient cell states. Using high-coverage single-cell RNA profiling, we asked whether long-term, heritable differences in gene expression can impart diversity within cells of the same type. Studying clonal human lymphocytes and mouse brain cells, we uncovered a vast diversity of heritable gene expression patterns among different clones of cells of the same type in vivo. We combined chromatin accessibility and RNA profiling on different lymphocyte clones to reveal thousands of regulatory regions exhibiting interclonal variation, which could be directly linked to interclonal variation in gene expression. Our findings identify a source of cellular diversity, which may have important implications for how cellular populations are shaped by selective processes in development, aging, and disease. A record of this paper's transparent peer review process is included in the supplemental information.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Weissman, Martin H.Mathematics Department, University of California, Santa Cruz, CA, USA (author)
  • Ratz, MichaelKTH,Genteknologi,Science for Life Laboratory, SciLifeLab,Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden(Swepub:kth)u1czhayh (author)
  • Hagemann-Jensen, MichaelDepartment of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden (author)
  • Hård, JoannaDepartment of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden (author)
  • Eriksson, Carl JohanDepartment of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden (author)
  • Toosi, HoseinKTH,Beräkningsvetenskap och beräkningsteknik (CST),Science for Life Laboratory, SciLifeLab(Swepub:kth)u1xua1k7 (author)
  • Bergenstråhle, JosephKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1ck6nue (author)
  • Ziegenhain, ChristophDepartment of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden (author)
  • von Berlin, LeonieDepartment of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden (author)
  • Martin, MarcelDepartment of Biochemistry and Biophysics, National Bioinformatics Infrastructure Sweden, SciLifeLab, Stockholm University, Stockholm, Sweden (author)
  • Blom, KimCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden (author)
  • Lagergren, JensKTH,Beräkningsvetenskap och beräkningsteknik (CST),Science for Life Laboratory, SciLifeLab(Swepub:kth)u13fcyg9 (author)
  • Lundeberg, JoakimKTH,Science for Life Laboratory, SciLifeLab,Genteknologi(Swepub:kth)u1qkn9kw (author)
  • Sandberg, RickardDepartment of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden (author)
  • Michaëlsson, JakobCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden (author)
  • Frisén, JonasDepartment of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden (author)
  • Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, SwedenMathematics Department, University of California, Santa Cruz, CA, USA (creator_code:org_t)

Related titles

  • In:Cell systems: Elsevier BV15:2, s. 149-2405-4720

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