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Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice

Masarapu, Yuvarani (author)
KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.
Cekanaviciute, Egle (author)
Space Biosciences Division, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field,NASA, Space Biosci Div, Ames Res Ctr, Moffett Field, CA 94035 USA.
Andrusivova, Zaneta (author)
KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.
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Westholm, Jakub O. (author)
National Bioinformatics Infrastructure Sweden, Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, Stockholm, Sweden,Stockholm Univ, Dept Biochem & Biophys, Natl Bioinformat Infrastruct Sweden, Sci Life Lab, Stockholm, Sweden.
Björklund, Åsa (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för cell- och molekylärbiologi
Fallegger, Robin (author)
Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany,Heidelberg Univ, Fac Med, Heidelberg, Germany.;Heidelberg Univ Hosp, Inst Computat Biomed, Bioquant, Heidelberg, Germany.
Badia-i-Mompel, Pau (author)
Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany; GSK, Cellzome, Heidelberg, Germany,Heidelberg Univ, Fac Med, Heidelberg, Germany.;Heidelberg Univ Hosp, Inst Computat Biomed, Bioquant, Heidelberg, Germany.;GSK, Cellzome, Heidelberg, Germany.
Boyko, Valery (author)
Space Biosciences Division, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field; Bionetics, Yorktown, VA, USA,NASA, Space Biosci Div, Ames Res Ctr, Moffett Field, CA 94035 USA.;Bionetics, Yorktown, VA USA.
Vasisht, Shubha (author)
Department of Biomedical and Health Informatics, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA,Childrens Hosp Philadelphia, Res Inst, Dept Biomed & Hlth Informat, Philadelphia, PA USA.
Saravia-Butler, Amanda (author)
KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field,NASA, KBR, Space Biosci Div, Ames Res Ctr, Mountain View, CA 94035 USA.
Gebre, Samrawit (author)
Space Biosciences Division, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field,NASA, Space Biosci Div, Ames Res Ctr, Moffett Field, CA 94035 USA.
Lázár, Enikő (author)
KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.;Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden.
Graziano, Marta (author)
Department of Neuroscience, Karolinska Institutet, Biomedicum, Solna, Sweden,Karolinska Inst, Dept Neurosci, Biomedicum, Solna, Sweden.
Frapard, Solene (author)
KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.
Hinshaw, Robert G. (author)
NASA Postdoctoral Program - Oak Ridge Associated Universities, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field,NASA, Postdoctoral Program, Oak Ridge Associated Univ, Ames Res Ctr, Moffett Field, CA 94035 USA.
Bergmann, Olaf (author)
Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden; Pharmacology and Toxicology, Department of Pharmacology and Toxicology University Medical Center Goettingen, Goettingen, Germany,Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden.;Univ Med Ctr Goettingen, Dept Pharmacol & Toxicol, Pharmacol & Toxicol, Gottingen, Germany.
Taylor, Deanne M. (author)
Department of Biomedical and Health Informatics, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA; Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, 19104, Philadelphia, PA, USA,Childrens Hosp Philadelphia, Res Inst, Dept Biomed & Hlth Informat, Philadelphia, PA USA.;Univ Penn, Perelman Sch Med, Dept Pediat, Philadelphia, PA 19104 USA.
Wallace, Douglas C. (author)
Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia and Department of Pediatrics, Division of Human Genetics, The University of Pennsylvania Perelman School of Medicine, 19104, Philadelphia, PA, USA,Univ Penn, Childrens Hosp Philadelphia, Ctr Mitochondrial & Epigenom Med, Perelman Sch Med, Philadelphia, PA 19104 USA.;Univ Penn, Perelman Sch Med, Dept Pediat, Div Human Genet, Philadelphia, PA 19104 USA.
Sylvén, Christer (author)
Department of Medicine, Karolinska Institute, Huddinge, Sweden,Karolinska Inst, Dept Med, Huddinge, Sweden.
Meletis, Konstantinos (author)
Department of Neuroscience, Karolinska Institutet, Biomedicum, Solna, Sweden,Karolinska Inst, Dept Neurosci, Biomedicum, Solna, Sweden.
Saez-Rodriguez, Julio (author)
Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany,Heidelberg Univ, Fac Med, Heidelberg, Germany.;Heidelberg Univ Hosp, Inst Computat Biomed, Bioquant, Heidelberg, Germany.
Galazka, Jonathan M. (author)
Space Biosciences Division, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field,NASA, Space Biosci Div, Ames Res Ctr, Moffett Field, CA 94035 USA.
Costes, Sylvain V. (author)
Space Biosciences Division, NASA Ames Research Center, Moffett Field, 94035, Mountain View, CA, USA, Moffett Field,NASA, Space Biosci Div, Ames Res Ctr, Moffett Field, CA 94035 USA.
Giacomello, Stefania (author)
KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden.
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 (creator_code:org_t)
Springer Nature, 2024
2024
English.
In: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
Related links:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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http://kipublication...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Impairment of the central nervous system (CNS) poses a significant health risk for astronauts during long-duration space missions. In this study, we employed an innovative approach by integrating single-cell multiomics (transcriptomics and chromatin accessibility) with spatial transcriptomics to elucidate the impact of spaceflight on the mouse brain in female mice. Our comparative analysis between ground control and spaceflight-exposed animals revealed significant alterations in essential brain processes including neurogenesis, synaptogenesis and synaptic transmission, particularly affecting the cortex, hippocampus, striatum and neuroendocrine structures. Additionally, we observed astrocyte activation and signs of immune dysfunction. At the pathway level, some spaceflight-induced changes in the brain exhibit similarities with neurodegenerative disorders, marked by oxidative stress and protein misfolding. Our integrated spatial multiomics approach serves as a stepping stone towards understanding spaceflight-induced CNS impairments at the level of individual brain regions and cell types, and provides a basis for comparison in future spaceflight studies. For broader scientific impact, all datasets from this study are available through an interactive data portal, as well as the National Aeronautics and Space Administration (NASA) Open Science Data Repository (OSDR).

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

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