SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:kth-352192"
 

Search: onr:"swepub:oai:DiVA.org:kth-352192" > Overactive WASp in ...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • He, MinghuiKarolinska Institutet (author)

Overactive WASp in X-linked neutropenia leads to aberrant B-cell division and accelerated plasma cell generation.

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier BV,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-352192
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-352192URI
  • https://doi.org/10.1016/j.jaci.2021.07.033DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:149067107URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: B-cell affinity maturation in germinal center relies on regulated actin dynamics for cell migration and cell-to-cell communication. Activating mutations in the cytoskeletal regulator Wiskott-Aldrich syndrome protein (WASp) cause X-linked neutropenia (XLN) with reduced serum level of IgA.OBJECTIVE: We investigated the role of B cells in XLN pathogenesis.METHODS: We examined B cells from 6 XLN patients, 2 of whom had novel R268W and S271F mutations in WASp. By using immunized XLN mouse models that carry the corresponding patient mutations, WASp L272P or WASp I296T, we examined the B-cell response.RESULTS: XLN patients had normal naive B cells and plasmablasts, but reduced IgA+ B cells and memory B cells, and poor B-cell proliferation. On immunization, XLN mice had a 2-fold reduction in germinal center B cells in spleen, but with increased generation of plasmablasts and plasma cells. In vitro, XLN B cells showed reduced immunoglobulin class switching and aberrant cell division as well as increased production of immunoglobulin-switched plasma cells.CONCLUSIONS: Overactive WASp predisposes B cells for premature differentiation into plasma cells at the expense of cell proliferation and immunoglobulin class switching.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Saeed, MezidaKarolinska Institutet(Swepub:kth)u1omomv1 (author)
  • Record, JulienKarolinska Institutet (author)
  • Keszei, MartonKarolinska Institutet (author)
  • Gonçalves Pinho, LiaKarolinska Institutet (author)
  • Vasconcelos-Fontes, Larissa (author)
  • D'Aulerio, RobertaKarolinska Institutet (author)
  • Vieira, RhaissaKarolinska Institutet (author)
  • Oliveira, Mariana M S (author)
  • Geyer, Chiara (author)
  • Bohaumilitzky, Lena (author)
  • Thiemann, Meike (author)
  • Deordieva, Ekaterina (author)
  • Buedts, Lieselot (author)
  • Matias Lopes, Joao Pedro (author)
  • Pershin, Dmitry (author)
  • Hammarström, LennartKarolinska Institutet (author)
  • Xia, Yu (author)
  • Zhao, Xiaodong (author)
  • Cunningham-Rundles, Charlotte (author)
  • Thrasher, Adrian J (author)
  • Burns, Siobhan O (author)
  • Cotta-de-Almeida, Vinicius (author)
  • Liu, Chaohong (author)
  • Shcherbina, Anna (author)
  • Vandenberghe, Peter (author)
  • Westerberg, Lisa SKarolinska Institutet (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Journal of Allergy and Clinical Immunology: Elsevier BV149:3, s. 1069-10840091-67491097-6825

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view