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SATB2 in Combinatio...
SATB2 in Combination With Cytokeratin 20 Identifies Over 95% of all Colorectal Carcinomas
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- Magnusson, Kristina (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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de Wit, Meike (author)
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Brennan, Donal J. (author)
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- Johnson, Louis Banka (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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Mcgee, Sharon F. (author)
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- Lundberg, Emma (author)
- KTH,Proteomik
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Naicker, Kirsha (author)
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Klinger, Rut (author)
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- Kampf, Caroline (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Asplund, Anna (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Wester, Kenneth (author)
- Uppsala universitet,Molekylär och morfologisk patologi,Enheten för biomedicinsk strålningsvetenskap,Institutionen för kirurgiska vetenskaper
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- Gry, Marcus (author)
- Uppsala universitet,KTH,Proteomik,Institutionen för genetik och patologi
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- Bjartell, Anders (author)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups
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Gallagher, William M. (author)
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Rexhepaj, Elton (author)
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Kilpinen, Sami (author)
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Kallioniemi, Olli-Pekka (author)
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Belt, Eric (author)
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Goos, Jeroen (author)
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Meijer, Gerrit (author)
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- Birgisson, Helgi (author)
- Uppsala universitet,Kolorektalkirurgi
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- Glimelius, Bengt (author)
- Uppsala universitet,Enheten för onkologi
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Borrebaeck, Carl A. K. (author)
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Navani, Sanjay (author)
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- Uhlén, Mathias (author)
- KTH,Proteomik
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O'Connor, Darran P. (author)
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- Jirström, Karin (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Pontén, Fredrik (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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(creator_code:org_t)
- 2011
- 2011
- English.
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In: American Journal of Surgical Pathology. - 0147-5185 .- 1532-0979. ; 35:7, s. 937-948
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- The special AT-rich sequence-binding protein 2 (SATB2), a nuclear matrix-associated transcription factor and epigenetic regulator, was identified as a tissue type-specific protein when screening protein expression patterns in human normal and cancer tissues using an antibody-based proteomics approach. In this respect, the SATB2 protein shows a selective pattern of expression and, within cells of epithelial lineages, SATB2 expression is restricted to glandular cells lining the lower gastrointestinal tract. The expression of SATB2 protein is primarily preserved in cancer cells of colorectal origin, indicating that SATB2 could function as a clinically useful diagnostic marker to distinguish colorectal cancer (CRC) from other types of cancer. The aim of this study was to further explore and validate the specific expression pattern of SATB2 as a clinical biomarker and to compare SATB2 with the well-known cytokeratin 20 (CK20). Immunohistochemistry was used to analyze the extent of SATB2 expression in tissue microarrays with tumors from 9 independent cohorts of patients with primary and metastatic CRCs (n = 1882). Our results show that SATB2 is a sensitive and highly specific marker for CRC with distinct positivity in 85% of all CRCs, and that SATB2 and/or CK20 was positive in 97% of CRCs. In conclusion, the specific expression of SATB2 in a large majority of CRCs suggests that SATB2 can be used as an important complementary tool for the differential diagnosis of carcinoma of unknown primary origin.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- SATB2
- colorectal cancer
- antibody-based proteomics
- diagnostic biomarker
- Bioengineering
- Bioteknik
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Magnusson, Krist ...
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de Wit, Meike
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Brennan, Donal J ...
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Johnson, Louis B ...
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Mcgee, Sharon F.
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Lundberg, Emma
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show more...
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Naicker, Kirsha
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Klinger, Rut
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Kampf, Caroline
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Asplund, Anna
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Wester, Kenneth
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Gry, Marcus
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Bjartell, Anders
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Gallagher, Willi ...
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Rexhepaj, Elton
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Kilpinen, Sami
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Kallioniemi, Oll ...
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Belt, Eric
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Goos, Jeroen
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Meijer, Gerrit
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Birgisson, Helgi
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Glimelius, Bengt
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Borrebaeck, Carl ...
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Navani, Sanjay
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Uhlén, Mathias
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O'Connor, Darran ...
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Jirström, Karin
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Pontén, Fredrik
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show less...
- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Industrial Biote ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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American Journal ...
- By the university
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Royal Institute of Technology
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Lund University
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Karolinska Institutet
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Uppsala University