Acute short-term hyperoxia followed by mild hypoxia does not increase EPO production: resolving the "normobaric oxygen paradox''

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Debevec, Tadej (author)

Acute short-term hyperoxia followed by mild hypoxia does not increase EPO production : resolving the "normobaric oxygen paradox''

Article/chapterEnglish2012

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2011-07-07
Springer Science and Business Media LLC,2012
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LIBRIS-ID:oai:DiVA.org:kth-44494
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-44494URI
https://doi.org/10.1007/s00421-011-2060-7DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:124267466URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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QC 20150629
Recent findings suggest that besides renal tissue hypoxia, relative decrements in tissue oxygenation, using a transition of the breathing mixture from hyperoxic to normoxic, can also stimulate erythropoietin (EPO) production. To further clarify the importance of the relative change in tissue oxygenation on plasma EPO concentration [EPO], we investigated the effect of a consecutive hyperoxic and hypoxic breathing intervention. Eighteen healthy male subjects were assigned to either IHH (N = 10) or CON (N = 8) group. The IHH group breathed pure oxygen (F(i)O(2) ~ 1.0) for 1 h, followed by a 1-h period of breathing a hypoxic gas mixture (F(i)O(2) ~ 0.15). The CON group breathed a normoxic gas mixture (F(i)O(2) ~ 0.21) for the same duration (2 h). Blood samples were taken just before, after 60 min, and immediately after the 2-h exposure period. Thereafter, samples were taken at 3, 5, 8, 24, 32, and 48 h after the exposure. During the breathing interventions, subjects remained in supine position. There were significant increases in absolute [EPO] within groups at 8 and 32 h in the CON and at 32 h only in the IHH group. No significant differences in absolute [EPO] were observed between groups following the intervention. Relative (∆[EPO]) levels were significantly lower in the IHH than in the CON group, 5 and 8 h following exposure. The tested protocol of consecutive hyperoxic-hypoxic gas mixture breathing did not induce [EPO] synthesis stimulation. Moreover, the transient attenuation in ∆[EPO] in the IHH group was most likely due to a hyperoxic suppression. Hence, our findings provide further evidence against the "normobaric O(2) paradox" theory.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
Erythropoiesis
Hyperoxemia
Individual variation
Diurnal variation

Added entries (persons, corporate bodies, meetings, titles ...)

Keramidas, Michail E. (author)
Norman, BarbaraKarolinska Institutet (author)
Gustafsson, ThomasKarolinska Institutet (author)
Eiken, OlaKTH,Omgivningsfysiologi(Swepub:kth)u1fcwvxl (author)
Mekjavic, Igor B. (author)
Karolinska InstitutetOmgivningsfysiologi (creator_code:org_t)

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In:European Journal of Applied Physiology: Springer Science and Business Media LLC112:3, s. 1059-10651439-63191439-6327

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