Erythropoietin concentrations during 10 days of normobaric hypoxia under controlled environmental circumstances.

Berglund, B (author)

Ornhagen, H (author)

Ostberg, C (author)

Wide, L (author): Uppsala universitet,Institutionen för medicinska vetenskaper,CLINICAL CHEMISTRY

(creator_code:org_t)

2002-03-20
2002
English.
In: Acta Physiologica Scandinavica. - : Wiley. - 0001-6772 .- 1365-201X. ; 174, s. 225-

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; http://kipublication...; https://urn.kb.se/re...; show less...

Abstract Subject headings

Serum erythropoietin levels (s-[epo]), haemoglobin concentration ([Hb]), haematocrit (hct), and ferritin concentration ([fer]) were measured in seven healthy male volunteers (20-23 years) exposed continuously to hypoxia (PO(2) 14 kPa) for 10 days. Serum erythropoietin concentration increased significantly from 9.5 +/- 3.51 to 33.6 +/- 11.64 U L(-1) (P < 0.05) after 2 days of hypoxia. Thereafter, s-[epo] decreased. However, after 10 days s-[epo] was 18.7 +/- 5.83 U L(-1) which was still increased above the pre-hypoxia level (P < 0.05). Serum haemoglobin concentration and hct increased over the 10 days of hypoxia, [Hb] from 152 +/- 8.9 to 168 +/- 9.2 gL(-1) (P < 0.001), and hct from 43 +/- 2.4 to 49 +/- 2.6% (P < 0.001). Ferritin concentration decreased significantly during the hypoxic exposure from 82 +/- 46.9 to 44 +/- 31.7 mmol L(-1) after 10 days (P < 0.01). In conclusion, the initial increase of s-[epo] under controlled normobaric hypoxia was marked, 353%, and levelled off after 5-10 days at 62-97% above normoxia level. There was also a significant increase in [Hb] and hct and a decrease in [fer] after 10 days of exposure to normobaric hypoxia.

By the author/editor: Berglund, B; Gennser, Mikael; Ornhagen, H; Ostberg, C; Wide, L

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Physiology

By the university: Royal Institute of Technology; Karolinska Institutet; Uppsala University

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