Search: onr:"swepub:oai:DiVA.org:kth-50744" > Nearest neighbor an...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03030naa a2200433 4500 | |
001 | oai:DiVA.org:kth-50744 | |
003 | SwePub | |
008 | 111207s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-507442 URI |
024 | 7 | a https://doi.org/10.1002/jemt.210462 DOI |
040 | a (SwePub)kth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Blom, Hansu KTH,Experimentell biomolekylär fysik4 aut0 (Swepub:kth)u1qhk3ta |
245 | 1 0 | a Nearest neighbor analysis of dopamine D1 receptors and Na plus -K plus -ATPases in dendritic spines dissected by STED microscopy |
264 | c 2011-08-01 | |
264 | 1 | b Wiley,c 2012 |
338 | a print2 rdacarrier | |
500 | a QC 20120309 | |
520 | a Protein localization in dendritic spines is the focus of intense investigations within neuroscience. Applications of super-resolution microscopy to dissect nanoscale protein distributions, as shown in this work with dual-color STED, generate spatial correlation coefficients having quite small values. This means that colocalization analysis to some extent looses part of its correlative impact. In this study we thus introduced nearest neighbor analysis to quantify the spatial relations between two important proteins in neurons, the dopamine D1 receptor and Na+,K+-ATPase. The analysis gave new information on how dense the D1 receptor and Na+,K+-ATPase constituting nanoclusters are located both with respect to the homogenous (self to same) and the heterogeneous (same to other) topology. The STED dissected nanoscale topologies provide evidence for both a joint as well as a separated confinement of the D1 receptor and the Na+,K+-ATPase in the postsynaptic areas of dendritic spines. This confined topology may have implications for generation of local sodium gradients and for structural and functional interactions modulating slow synaptic transmission processes. Microsc. Res. Tech., 2011. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologi0 (SwePub)3042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnology0 (SwePub)3042 hsv//eng |
653 | a fluorescence microscopy | |
653 | a STED | |
653 | a localization | |
653 | a striatal neurons | |
700 | 1 | a Rönnlund, Danielu KTH,Experimentell biomolekylär fysik4 aut0 (Swepub:kth)u1vmbh2t |
700 | 1 | a Scott, Lena4 aut |
700 | 1 | a Spicarova, Zuzana4 aut |
700 | 1 | a Rantanen, Ville4 aut |
700 | 1 | a Widengren, Jerkeru KTH,Experimentell biomolekylär fysik4 aut0 (Swepub:kth)u1i3g09c |
700 | 1 | a Aperia, Anita4 aut |
700 | 1 | a Brismar, Hjalmaru KTH,Cellens fysik4 aut0 (Swepub:kth)u1232ew5 |
710 | 2 | a KTHb Experimentell biomolekylär fysik4 org |
773 | 0 | t Microscopy research and technique (Print)d : Wileyg 75:2, s. 220-228q 75:2<220-228x 1059-910Xx 1097-0029 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-50744 |
856 | 4 8 | u https://doi.org/10.1002/jemt.21046 |
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