Search: onr:"swepub:oai:DiVA.org:kth-58863" >
Extracorporeal memb...
-
Holzgraefe, B.Karolinska Institutet
(author)
Extracorporeal membrane oxygenation for pandemic H1N1 2009 respiratory failure
- Article/chapterEnglish2010
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:DiVA.org:kth-58863
-
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-58863URI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:121900075URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
QC 20120116
-
BACKGROUND: Severe respiratory failure related to infection with the pandemic influenza A/H1N1 2009 virus is uncommon but possibly life-threatening. If, in spite of maximal conventional critical care, the patient's condition deteriorates, extracorporeal membrane oxygenation (ECMO) may be a life-saving procedure. METHODS: An observational study approved by the local ethics committee was carried out. Data from all patients treated with ECMO at the ECMO Center Karolinska for influenza A/H1N1 2009-related severe respiratory failure were analyzed. The main outcome measure was survival three months after discharge from our department. RESULTS: Between July 2009 and January 2010, 13 patients with H1N1 2009 respiratory failure were treated with ECMO. Twelve patients were cannulated for veno-venous ECMO at the referring hospital and transported to Stockholm. One patient was cannulated in our hospital for veno-arterial support. The median ratio of the arterial partial oxygen pressure to the fraction of inspired oxygen (P/F ratio: PaO2 /FiO2) before cannulation was 52.5 (interquartile range 38-60). Four patients were converted from veno-venous to veno-arterial ECMO because of right heart failure (three) or life-threatening cardiac arrhythmias (one). The median maximum oxygen consumption via ECMO was 251 ml/min (187-281 ml/min). Twelve patients were still alive three months after discharge; one patient died four days after discharge due to intracranial hemorrhage. CONCLUSION: Patients treated with veno-venous or veno-arterial ECMO for H1N1 2009-related respiratory failure may have a favorable outcome. Contributing factors may include the possibility of transport on ECMO, conversion from veno-venous (v-v) or veno-arterial (v-a) ECMO if necessary, high-flow ECMO to meet oxygen requirements and active surgery when needed.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Broome, MichaelKarolinska Institutet(Swepub:kth)u1boiixx
(author)
-
Kalzen, H.
(author)
-
Konrad, D.Karolinska Institutet
(author)
-
Palmer, K.
(author)
-
Frenckner, B.Karolinska Institutet
(author)
-
Karolinska Institutet
(creator_code:org_t)
Related titles
-
In:Minerva Anestesiologica76:12, s. 1043-10510375-93931827-1596
Internet link
Find in a library
To the university's database