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Glcci1 Deficiency L...
Glcci1 Deficiency Leads to Proteinuria
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Nishibori, Yukino (author)
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- Katayama, Kan (author)
- Karolinska Institutet
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Parikka, Mataleena (author)
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Oddsson, Asmundur (author)
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Nukui, Masatoshi (author)
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Hultenby, Kjell (author)
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- Wernerson, Annika (author)
- Karolinska Institutet
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- He, Bing (author)
- Karolinska Institutet
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- Ebarasi, Lwaki (author)
- Karolinska Institutet
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- Raschperger, Elisabeth (author)
- Karolinska Institutet
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Norlin, Jenny (author)
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- Uhlen, Mathias (author)
- KTH,Proteomik
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- Patrakka, Jaakko (author)
- Karolinska Institutet
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- Betsholtz, Christer (author)
- Karolinska Institutet
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Tryggvason, Karl (author)
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(creator_code:org_t)
- 2011
- 2011
- English.
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In: Journal of the American Society of Nephrology. - 1046-6673 .- 1533-3450. ; 22:11, s. 2037-2046
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Unbiased transcriptome profiling and functional genomics approaches identified glucocorticoid-induced transcript 1 (GLCCI1) as being a transcript highly specific for the glomerulus, but its role in glomerular development and disease is unknown. Here, we report that mouse glomeruli express far greater amounts of Glcci1 protein compared with the rest of the kidney. RT-PCR and Western blotting demonstrated that mouse glomerular Glcci1 is approximately 60 kD and localizes to the cytoplasm of podocytes in mature glomeruli. In the fetal kidney, intense Glcci1 expression occurs at the capillary-loop stage of glomerular development. Using gene knockdown in zebrafish with morpholinos, morphants lacking Glcci1 function had collapsed glomeruli with foot-process effacement. Permeability studies of the glomerular filtration barrier in these zebrafish morphants demonstrated a disruption of the selective glomerular permeability filter. Taken together, these data suggest that Glcci1 promotes the normal development and maintenance of podocyte structure and function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- GLOMERULAR TRANSCRIPTOME; GENE-EXPRESSION; KIDNEY; CELL; ZEBRAFISH; PODOCIN; IDENTIFICATION; LOCALIZES; NEPHRIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Nishibori, Yukin ...
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Katayama, Kan
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Parikka, Matalee ...
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Oddsson, Asmundu ...
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Nukui, Masatoshi
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Hultenby, Kjell
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show more...
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Wernerson, Annik ...
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He, Bing
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Ebarasi, Lwaki
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Raschperger, Eli ...
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Norlin, Jenny
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Uhlen, Mathias
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Patrakka, Jaakko
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Betsholtz, Chris ...
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Tryggvason, Karl
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Journal of the A ...
- By the university
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Royal Institute of Technology
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Karolinska Institutet