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- Söderqvist, EmilDepartment of Medical Engineering, Karolinska Institutet, Stockholm, Sweden (author)
The assessment of acute load and contractility changes by left ventricular pressure measurements
- Article/chapterEnglish2006
Publisher, publication year, extent ...
- 2006-10-25
- IOP Publishing,2006
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:kth-6522
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-6522URI
- https://doi.org/10.1088/0967-3334/27/12/003DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-153034URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:1946973URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- QC 20100922
- The aim of this study was to establish whether analysis of the left ventricular pressure waveform provides indicative information about cardiac load and contractility and to develop an algorithm for computer-based assessment of changes in these variables. In eight healthy standard breed anaesthetized open-chest pigs, a high frequency response guide-wire mounted pressure sensor was introduced into the left ventricle. Preload reduction was induced by vena cava occlusion, afterload increase by an i.v. injection of phenylephrine and increased contractility by an i.v. injection of adrenalin. Left ventricular pressure waveform analysis was performed by plotting the slope of the pressure curve during the systolic ejection period versus maximal systolic pressure. The analysis revealed characteristic changes in left ventricular pressure and pressure waveform and identified easily discernible reaction patterns in the slope versus maximal pressure plot, specific for each provocation. Analysis of the left ventricular waveform provides indicative information about loading conditions and contractility. The proposed algorithm can easily be implemented in pressure monitoring systems allowing real-time assessment and discrimination of acute changes in preload, afterload and myocardial performance.
Subject headings and genre
- TEKNIK OCH TEKNOLOGIER Medicinteknik Medicinsk laboratorie- och mätteknik hsv//swe
- ENGINEERING AND TECHNOLOGY Medical Engineering Medical Laboratory and Measurements Technologies hsv//eng
- monitoring
- left ventricle
- pressure waves
- loading conditions
- contractility
- Medical engineering
- Medicinsk teknik
- MEDICINE
Added entries (persons, corporate bodies, meetings, titles ...)
- Hultman, JanUppsala universitet,Institutionen för kirurgiska vetenskaper (author)
- Källner, GöranKarolinska Institutet (author)
- Nowak, JacekKarolinska Institutet (author)
- Brodin, Lars-ÅkeKarolinska Institutet(Swepub:kth)u1jq9s27 (author)
- Department of Medical Engineering, Karolinska Institutet, Stockholm, SwedenInstitutionen för kirurgiska vetenskaper (creator_code:org_t)
Related titles
- In:Physiological Measurement: IOP Publishing27:12, s. 1281-12920967-33341361-6579
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